Wei Xiaomin, E Meng, Yu Sufang
Institute of Occupational Health and Environmental, Health, Shandong University, 44 Wenhua Xi Road, Jinan, 250012 Shandong, PR China.
Institute of Occupational Health and Environmental, Health, Shandong University, 44 Wenhua Xi Road, Jinan, 250012 Shandong, PR China.
Diabetes Res Clin Pract. 2015 Jan;107(1):9-14. doi: 10.1016/j.diabres.2014.09.019. Epub 2014 Oct 14.
To assess passive smoking as a risk factor for developing type 2 Diabetes Mellitus (T2DM).
A search of PubMed, Web of Knowledge, Elsevier ScienceDirect and Springer (up to March, 2014) databases were performed using subject and random words. Two authors independently extracted the data. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of included studies. The odds ratio (ORs) for the association was determined using a fix-effects model. Subgroup and sensitivity analyses were performed and publication bias was assessed.
7 prospective studies were included in this meta-analysis which included a total of 162,001 subjects. The overall OR for developing T2DM for passive smoking was 1.33 (95% confidence interval (CI) 1.20-1.46), with no significant heterogeneity between studies. The result was stable in the subgroup and sensitivity analyses, however there was evidence of publication bias. After the "fill and trim" method, the recalculated OR was 1.27 (95%CI 1.16-1.40).
Passive smoking is a risk factor of T2DM even in those who were not themselves active smokers.
评估被动吸烟作为2型糖尿病（T2DM）发病的一个危险因素。
利用主题词和随机词检索了PubMed、Web of Knowledge、爱思唯尔科学Direct和施普林格（截至2014年3月）数据库。两位作者独立提取数据。采用纽卡斯尔-渥太华量表（NOS）评估纳入研究的质量。使用固定效应模型确定关联的比值比（OR）。进行亚组分析和敏感性分析，并评估发表偏倚。
该荟萃分析纳入了7项前瞻性研究，共162,001名受试者。被动吸烟导致患T2DM的总体OR为1.33（95%置信区间（CI）1.20 - 1.46），各研究之间无显著异质性。在亚组分析和敏感性分析中结果稳定，然而有发表偏倚的证据。采用“填充和修剪”方法后，重新计算的OR为1.27（95%CI 1.16 - 1.40）。
即使对于那些本身不主动吸烟的人，被动吸烟也是T2DM的一个危险因素。
