围手术期输血治疗对局部晚期喉癌复发潜能的影响。

Influence of perioperative transfusion therapy on the recurrence potential of locally advanced laryngeal carcinoma.

作者信息

Bongioannini G, Vercellino M, Rugiu M G, Ferreri A, Succo G, Cortesina G

机构信息

II Clinica Otorinolaringoiatrica, Università degli Studi di Torino, Italia.

出版信息

ORL J Otorhinolaryngol Relat Spec. 1990;52(4):260-4. doi: 10.1159/000276146.

DOI:10.1159/000276146

PMID:2392289

Abstract

The present study was undertaken to determinate whether immunosuppression, induced by perioperative allogenic whole-blood transfusions (AWBTs), adversely affects prognosis after total resection of laryngeal cancer by promoting the appearance of recurrences. We studied 62 patients, aged 37-82 years with TNM stage III and IV (UICC, 1987) laryngeal cancer treated between 1977 and 1983. AWBTs were administered to 30/62 patients perioperatively. All patients were followed up for 4 years. After 4 years we found the following disease-free survival indexes: transfused, 12/30 (40%); nontransfused, 22/32 (70%; p less than 0.05). On the base of these dates, we conclude that AWBTs exert a significant influence on early recurrence and on survival in patients with laryngeal cancer.

摘要

本研究旨在确定围手术期异体全血输注（AWBTs）所诱导的免疫抑制是否会通过促进复发的出现而对喉癌全切除术后的预后产生不利影响。我们研究了62例年龄在37 - 82岁之间、TNM分期为III期和IV期（UICC，1987）的喉癌患者，这些患者在1977年至1983年间接受治疗。30/62例患者在围手术期接受了AWBTs。所有患者均随访4年。4年后，我们发现以下无病生存指标：接受输血者，12/30（40%）；未输血者，22/32（70%；p<0.05）。基于这些数据，我们得出结论，AWBTs对喉癌患者的早期复发和生存有显著影响。