a Department of Chemistry , Kwangwoon University , Seoul , Korea.
Drug Deliv. 2016 Sep;23(7):2262-2271. doi: 10.3109/10717544.2014.970297. Epub 2014 Oct 15.
This review is aimed to discuss the molecular imprinted polymer (MIP)-based drug delivery systems (DDS). Molecular imprinted polymers have proved to possess the potential and also as a suitable material in several areas over a long period of time. However, only recently it has been employed for pharmaceuticals and biomedical applications, particularly as drug delivery vehicles due to properties including selective recognition generated from imprinting the desired analyte, favorable in harsh experimental conditions, and feedback-controlled recognitive drug release. Hence, this review will discuss their synthesis, the reason they are selected as drug delivery vehicles and for their applications in several drug administration routes (i.e. transdermal, ocular and gastrointestinal or stimuli-reactive routes).
本综述旨在讨论基于分子印迹聚合物（MIP）的药物传递系统（DDS）。分子印迹聚合物已被证明在很长一段时间内具有潜力，并成为多个领域的合适材料。然而，直到最近，它才被用于制药和生物医学应用，特别是作为药物传递载体，因为其具有一些特性，包括印迹所需分析物所产生的选择性识别、在恶劣实验条件下的良好性能，以及反馈控制的识别药物释放。因此，本综述将讨论它们的合成、作为药物传递载体的选择原因，以及它们在几种药物给药途径（即经皮、眼和胃肠或刺激反应途径）中的应用。
