Cunliffe David, Kirby Andrew, Alexander Cameron
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Adv Drug Deliv Rev. 2005 Dec 6;57(12):1836-53. doi: 10.1016/j.addr.2005.07.015. Epub 2005 Oct 13.
Imprinted polymers are well established as molecular recognition materials but are now being increasingly considered for active biomedical applications such as drug delivery. In this review some highlights of recent research into molecularly imprinted drug delivery and controlled release systems are presented. The key factors controlling recognition and release by imprinted polymer matrices are discussed, the current limiting factors in their properties arising from the synthesis of these materials are considered, and the future prospects for imprinted polymers in drug delivery are outlined.
印迹聚合物作为分子识别材料已得到广泛认可，但现在越来越多地被考虑用于药物递送等活性生物医学应用。在这篇综述中，介绍了分子印迹药物递送和控释系统近期研究的一些亮点。讨论了控制印迹聚合物基质识别和释放的关键因素，考虑了这些材料合成过程中其性能方面当前的限制因素，并概述了印迹聚合物在药物递送方面的未来前景。
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