Grysko M, Daniels R
Pharmazeutische Technologie und Biopharmazie, Pharmazeutisches Institut, Universität Tübingen, Germany.
Pharmazie. 2013 Jul;68(7):572-7.
Oleogels are known for their high physical, chemical, and mechanical stability and good in vivo efficacy, which make them appropriate vehicles for dermal drug delivery and skin care for very dry skin. Modern formulation research focusses on well tolerated and sustainable formulation concepts. This paper deals with an innovative oleogel, which is based on a triterpene dry extract from the outer bark of birch (TE). In this formulation TE does not only act as an excipient but provides interesting pharmacological properties at the same time. The oleogel was formulated using solely Simmondsia Chinensis seed oil (jojoba oil) and TE. Fluorescence microscopy and confocal Raman microscopy showed that suspended TE particles arrange in a three-dimensional gel network. Infrared spectroscopy revealed that the formation of hydrogen bonds between TE particles is responsible for the self-assembly of TE in oil. Moreover, the influence of TE concentration and morphology of the TE particles on the viscoelasticity of the resulting oleogels was analyzed. Gel strength increased with TE concentration and was critical to the specific surface area of the TE particles.
油凝胶以其高物理、化学和机械稳定性以及良好的体内功效而闻名，这使其成为用于干性皮肤的皮肤药物递送和皮肤护理的合适载体。现代制剂研究集中在耐受性良好且可持续的制剂概念上。本文涉及一种创新的油凝胶，它基于桦树外皮的三萜干提取物（TE）。在这种制剂中，TE不仅作为辅料，同时还具有有趣的药理特性。该油凝胶仅使用西蒙得木籽油（霍霍巴油）和TE配制而成。荧光显微镜和共聚焦拉曼显微镜显示，悬浮的TE颗粒排列成三维凝胶网络。红外光谱表明，TE颗粒之间氢键的形成是TE在油中自组装的原因。此外，还分析了TE浓度和TE颗粒形态对所得油凝胶粘弹性的影响。凝胶强度随TE浓度增加而增加，并且对TE颗粒的比表面积至关重要。
