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静电纺丝聚乳酸（PLA）纤维载桦树皮三萜提取物的制备及表征用于伤口敷料。

Preparation and Characterization of Electrospun Polylactic Acid (PLA) Fiber Loaded with Birch Bark Triterpene Extract for Wound Dressing.

机构信息

The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.

Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing, China.

出版信息

AAPS PharmSciTech. 2021 Jul 20;22(6):205. doi: 10.1208/s12249-021-02081-z.

DOI:10.1208/s12249-021-02081-z
PMID:34286391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8292269/
Abstract

Drug-loaded electrospun fibers have attracted increasing attention as a promising wound dressing material due to their capability of preventing from infections and inflammation and maintaining an appropriate environment for wound healing. In this study, polylactic acid (PLA), which is widely used in wound management, was chosen as electrospinnable polymer. A triterpene extract (TE) from the outer bark of birch known for its anti-inflammatory, antiviral, antibacterial, and wound healing effects was chosen to produce TE-loaded PLA electrospun fibers for wound dressing. A binary solvent system of dichloromethane (DCM) and dimethyl sulfoxide (DMSO) was employed, and the ratio of the solvents was optimized for preparing smooth and uniform fibers. The morphology of TE-loaded PLA electrospun fibers was investigated by scanning electron microscopy (SEM). The entrapment of TE in PLA fibers was confirmed by confocal laser scanning microscopy (CLSM). Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the solid state of TE in PLA fibers. The release behavior of TE was assayed by a shaking flask method for a period of 96 h. The results revealed that TE-loaded electrospun PLA microfibers could be reliably prepared and are promising future candidates in wound therapy.

摘要

载药电纺纤维因其能够预防感染和炎症以及维持适当的伤口愈合环境而作为一种有前途的伤口敷料材料受到越来越多的关注。在本研究中，选择了聚乳酸（PLA）作为可电纺聚合物，它广泛用于伤口管理。桦树皮中一种具有抗炎、抗病毒、抗菌和伤口愈合作用的三萜提取物（TE）被选择用于制备用于伤口敷料的载 TE 的 PLA 电纺纤维。使用了二氯甲烷（DCM）和二甲基亚砜（DMSO）的二元溶剂体系，并优化了溶剂的比例以制备光滑均匀的纤维。通过扫描电子显微镜（SEM）研究了载 TE 的 PLA 电纺纤维的形态。共聚焦激光扫描显微镜（CLSM）证实了 TE 在 PLA 纤维中的包封。差示扫描量热法（DSC）和 X 射线衍射（XRD）用于分析 TE 在 PLA 纤维中的固体状态。通过摇瓶法在 96 h 内测定了 TE 的释放行为。结果表明，载药电纺 PLA 微纤维可以可靠地制备，并且是伤口治疗中很有前途的候选材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/aed149f1e298/12249_2021_2081_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/e9dff8e9d2b6/12249_2021_2081_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/1e4fafe9541c/12249_2021_2081_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/0eaf161b9275/12249_2021_2081_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/31d3753e5a40/12249_2021_2081_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/928eb5671699/12249_2021_2081_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/aed149f1e298/12249_2021_2081_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/e9dff8e9d2b6/12249_2021_2081_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/1e4fafe9541c/12249_2021_2081_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/0eaf161b9275/12249_2021_2081_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/31d3753e5a40/12249_2021_2081_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/928eb5671699/12249_2021_2081_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2a/8292269/aed149f1e298/12249_2021_2081_Fig6_HTML.jpg

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2
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3
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Tissue Eng Regen Med. 2024 Oct;21(7):1007-1019. doi: 10.1007/s13770-024-00655-z. Epub 2024 Jun 14.
4
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Materials (Basel). 2024 Jan 26;17(3):608. doi: 10.3390/ma17030608.
5
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