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J Int Soc Sports Nutr. 2013 Aug 7;10(1):37. doi: 10.1186/1550-2783-10-37.
Magnolia (Magnolia officinalis) and Phellodendron (Phellodendron amurense) barks are medicinal plants commonly used as traditional remedies for reducing stress and anxiety. Modern dietary supplements are intended to induce relaxation and reduce stress as well as stress-related eating. Previous studies have shown the combination of Magnolia/Phellodendron (MP) to reduce both cortisol exposure and the perception of stress/anxiety, while improving weight loss in subjects with stress-related eating. Competitive athletes are "stressed" by their intense exercise regimens in addition to their normal activities of daily living and thus may benefit from a natural therapy intended to modulate baseline perceptions of stress and stress hormone exposure.
We assessed salivary cortisol exposure and psychological mood state in 56 subjects (35 men and 21 women) screened for moderate stress and supplemented with a standardized/patented MP combination (Relora®, Next Pharmaceuticals) or Placebo for 4 weeks.
After 4 weeks of supplementation, salivary cortisol exposure was significantly (p<0.05) lower (-18%) in the Relora group compared to Placebo. Compared to Placebo, the Relora group had significantly better (p<0.05) mood state parameters, including lower indices of Overall Stress (-11%), Tension (-13%), Depression (-20%), Anger (-42%), Fatigue (-31%), and Confusion (-27%), and higher indices of Global Mood State (+11%) and Vigor (+18%).
These results indicate that daily supplementation with a combination of Magnolia bark extract and Phellodendron bark extract (Relora®) reduces cortisol exposure and perceived daily stress, while improving a variety of mood state parameters, including lower fatigue and higher vigor. These results suggest an effective natural approach to modulating the detrimental health effects of chronic stress in moderately stressed adults. Future studies should examine the possible performance and recovery benefits of Relora supplementation in athletes overstressed by the physical and psychological demands of training and competition.
厚朴（Magnolia officinalis）和黄柏（Phellodendron amurense）树皮是药用植物，常用于减轻压力和焦虑的传统疗法。现代膳食补充剂旨在诱导放松、减轻压力和与压力相关的进食。先前的研究表明，厚朴/黄柏（MP）的组合可降低皮质醇的暴露和对压力/焦虑的感知，同时改善有压力相关进食的受试者的体重减轻。竞技运动员除了日常的生活活动外，还因剧烈的运动方案而“承受压力”，因此可能受益于旨在调节压力和应激激素暴露的基础感知的自然疗法。
我们评估了 56 名（35 名男性和 21 名女性）筛选出中度压力的受试者的唾液皮质醇暴露和心理情绪状态，并在 4 周内补充标准化/专利的 MP 组合（Relora®，Next Pharmaceuticals）或安慰剂。
补充 4 周后，与安慰剂组相比，Relora 组的唾液皮质醇暴露显著降低（p<0.05）（-18%）。与安慰剂组相比，Relora 组的情绪状态参数显著改善（p<0.05），包括总压力（-11%）、紧张（-13%）、抑郁（-20%）、愤怒（-42%）、疲劳（-31%）和困惑（-27%）指数降低，以及全球情绪状态（+11%）和活力（+18%）指数升高。
这些结果表明，每日补充厚朴提取物和黄柏提取物的组合（Relora®）可降低皮质醇暴露和感知的日常压力，同时改善多种情绪状态参数，包括疲劳降低和活力升高。这些结果表明，在训练和比赛的身体和心理需求使运动员过度紧张的情况下，这是一种有效调节慢性压力对健康的不利影响的自然方法。未来的研究应检查 Relora 补充剂对过度紧张的运动员的可能表现和恢复益处。
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