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合成具有非环 D-核糖基或 4-羟丁基链取代核糖的新型阿昔洛韦（AICA-核苷）类似物。

Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.

机构信息

Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, Napoli 80131, Italy.

出版信息

Molecules. 2013 Aug 6;18(8):9420-31. doi: 10.3390/molecules18089420.

DOI:10.3390/molecules18089420
PMID:23924994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6269997/
Abstract

The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a D-ribityl or by a hydroxybutyl chain.

摘要

某些无环核苷的抗病毒活性引起了我们的注意，即通过用带有羟基的烷基取代呋喃糖环，可以对这些核苷的生物学性质进行有用的结构修饰。在此，我们报告了一些新型阿昔洛韦类似物的合成，其中核糖部分由 D-核糖基或羟丁基链模拟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41f/6269997/e274115eec2f/molecules-18-09420-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41f/6269997/0ff525c0b146/molecules-18-09420-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41f/6269997/1512ac73ed09/molecules-18-09420-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41f/6269997/e274115eec2f/molecules-18-09420-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41f/6269997/0ff525c0b146/molecules-18-09420-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41f/6269997/1512ac73ed09/molecules-18-09420-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41f/6269997/e274115eec2f/molecules-18-09420-g003.jpg

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1
Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.合成具有非环 D-核糖基或 4-羟丁基链取代核糖的新型阿昔洛韦（AICA-核苷）类似物。
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5-氨基-1-(2',3'-异亚丙基-D-核醇基)-1-咪唑-4-甲酰胺：一种α = 4的晶体结构
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