Kukhanova M K
Mol Biol (Mosk). 2012 Nov-Dec;46(6):860-73.
This review provides data on the design of antiretroviral drugs based on nucleoside analogs. About 30 drugs were approved for the treatment of HIV-infected patients over 25 years. Seven nucleoside drugs are inhibitors of HIV reverse transcriptase and clinically used in combination with inhibitors of other viral enzymes, integrase and protease, and non-nucleoside inhibitors of reverse transcriptase. Toxicity of nucleoside drugs and approaches to obtaining of safe anti-HIV drugs are discussed. The results of developing of domestic anti-HIV drugs are presented. The future prospects of anti-HIV investigations are considered.
本综述提供了基于核苷类似物的抗逆转录病毒药物设计的数据。25年来，约有30种药物被批准用于治疗HIV感染患者。七种核苷药物是HIV逆转录酶抑制剂，临床上与其他病毒酶（整合酶和蛋白酶）抑制剂以及逆转录酶非核苷抑制剂联合使用。讨论了核苷药物的毒性以及获得安全抗HIV药物的方法。介绍了国产抗HIV药物的研发成果。还探讨了抗HIV研究的未来前景。
