钯(II)催化室温下芳基邻位 sp3 C-H 键的酰苯胺的氧化同偶联和交叉偶联反应。
Palladium(II)-Catalyzed Oxidative Homo- and Cross-Coupling of Aryl ortho-sp C-H Bonds of Anilides at Room Temperature.
机构信息
Department of Chemistry , Shanghai Jiao Tong University , 800 Dongchuan Road , Shanghai 200240 , China.
出版信息
J Org Chem. 2018 Apr 20;83(8):4812-4823. doi: 10.1021/acs.joc.8b00120. Epub 2018 Apr 9.
PMID:29613795
Abstract
The preparation of secondary 2,2'-bisanilides has been successfully achieved through an oxidative coupling of aryl ortho-sp C-H bonds of anilides in the presence of catalytic Pd(OAc) and KSO as an oxidant in MsOH/CFCOH (TFA) at room temperature (25 °C). The aromatic rings of anilides substituted by various electron-donating or electron-withdrawing groups are tolerant in these coupling reactions.
摘要
通过在醋酸钯和 KSO 的催化下，以 MsOH/CFCOH（TFA）为溶剂，在室温（25°C）下，成功实现了芳基邻位 sp² C-H 键的氧化偶联，从而制备了二级 2,2'-双苯甲酰基。在这些偶联反应中，取代基为各种给电子或吸电子基团的苯甲酰胺的芳环具有很好的耐受性。
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