Pureza Vincent, Florea Viorel G
Department of Internal Medicine, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN, 55455, USA,
Curr Heart Fail Rep. 2013 Dec;10(4):307-14. doi: 10.1007/s11897-013-0153-9.
The combination of profound muscle wasting and severe weight loss that occurs in heart failure is a complex phenomenon that involves the interplay of numerous factors. In this article, we describe processes that contribute to cachexia, as part of the clinical sequelae of heart failure, and their potential underlying mechanisms. While multiple mechanisms of cardiac cachexia have been described, we propose a multifactorial etiology for this condition that includes, but is not limited to, nutritional and gastrointestinal alterations, immunological and neurohormonal activation, and anabolic and catabolic imbalance.
心力衰竭时出现的严重肌肉萎缩和体重严重减轻相结合是一种复杂的现象，涉及众多因素的相互作用。在本文中，我们描述了作为心力衰竭临床后遗症一部分的恶病质促成过程及其潜在的潜在机制。虽然已经描述了心脏恶病质的多种机制，但我们提出这种情况的多因素病因，包括但不限于营养和胃肠道改变、免疫和神经激素激活以及合成代谢和分解代谢失衡。
