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[局限性硬皮病、萎缩性硬化性苔藓及慢性游走性红斑患者抗伯氏疏螺旋体抗体的测定]

[Determination of antibodies against Borrelia burgdorferi in patients with morphea, lichen sclerosus et atrophicus and erythema chronicum migrans].

作者信息

Pinazo Canales I, Betlloch Mas I, Mestre Bauza F, Salva Armengod F, Parras Vázquez F, Alomar Cardell J

机构信息

Unidad de Dermatología, Hospital Son Dureta, Palma de Mallorca.

出版信息

Rev Clin Esp. 1990 Apr;186(7):320-3.

PMID:2392594
Abstract

Several cutaneous entities described in Europe as Chronic Migrans Erythema (CME), Mild Cutis Lymphadenosis (MCL) and Chronic Atrophyc Acrodermatitis (CAA) constitute clinical manifestations of a Borrellia Burgdorferi. The presence of clinical and hystologic lesions similar to those of liquen esclerosus and atrophyc (LEA) and localized esclerodermia (morphea) in patients with CAA has driven to several authors to demonstrate the aethiologic participation of B. Burgdorferi in patients carrying those cutaneous lesions with contradictory results. A serologic study with indirect immunofluorescence (IIF) and FIAX test was performed in 16 patients (9 with morphea, 6 with LEA and 1 with CME) in order to evaluate the role of this microorganism in our environment. Five reactive sera were obtained of which only one presented IgG antibodies titrated at 1/256. The IgM antibodies by IIF and IgG by FIAX test turned out to be negative. A specific relationship between B. Burgdorferi and the studied entities could not be established.

摘要

在欧洲被描述为慢性游走性红斑(CME)、轻度皮肤淋巴结病(MCL)和慢性萎缩性肢端皮炎(CAA)的几种皮肤病症是伯氏疏螺旋体的临床表现。CAA患者中存在与硬化性苔藓和萎缩性苔藓(LEA)以及局限性硬皮病(硬斑病)相似的临床和组织学病变,这促使一些作者去证明伯氏疏螺旋体在患有这些皮肤病变患者中的病因学作用,但结果相互矛盾。为了评估这种微生物在我们环境中的作用,对16例患者(9例硬斑病、6例LEA和1例CME)进行了间接免疫荧光(IIF)和FIAX试验的血清学研究。获得了5份反应性血清,其中只有1份呈现IgG抗体滴度为1/256。IIF检测的IgM抗体和FIAX试验的IgG抗体结果均为阴性。无法确定伯氏疏螺旋体与所研究病症之间的特定关系。

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