Lyngbye T, Jørgensen P J, Grandjean P, Hansen O N
Department of Environmental Medicine, Odense University, Denmark.
Scand J Clin Lab Invest. 1990 Jun;50(4):441-9. doi: 10.3109/00365519009091604.
Blood lead concentrations were measured in a group of children from a group of 9- to 10-year-old school children in Aarhus, Denmark. The study group was selected as a high-level and a low-level lead group, as identified by the lead concentration in the circumpulpal dentine in deciduous teeth shed 2-3 years previously. The validity of the blood sampling technique was investigated in adult volunteers, and lead was determined by electrothermal atomic absorption. Capillary blood sampling by a finger-stick method was preferred, as the slight contamination caused by this technique was deemed acceptable. The children with the highest dentine lead levels (n = 70), had blood lead concentrations of 0.08-0.63 mumol/l and a geometric mean of 0.28 mumol/l. The children with lowest dentine levels (n = 76) had blood lead concentrations of 0.08-0.70 mumol/l and a geometric mean of 0.18 mumol/l. The blood lead concentrations were compared with interview data on behaviour, family habits, diet, parents' tobacco smoking and occupation, water lead measurements, and traffic counts. A total of 20% of the variation in blood lead was explained by parents' tobacco smoking, the child's number in the sibship, gender, and consumption of canned food at home.
对丹麦奥胡斯一群9至10岁学童中的一组儿童进行了血铅浓度测量。根据2至3年前脱落的乳牙牙髓周围牙本质中的铅浓度，将研究组分为高铅组和低铅组。在成年志愿者中研究了采血技术的有效性，并用石墨炉原子吸收法测定铅含量。由于认为这种技术造成的轻微污染是可以接受的，因此首选手指穿刺法采集毛细血管血。牙本质铅含量最高的儿童（n = 70），血铅浓度为0.08 - 0.63 μmol/l，几何平均数为0.28 μmol/l。牙本质铅含量最低的儿童（n = 76），血铅浓度为0.08 - 0.70 μmol/l，几何平均数为0.18 μmol/l。将血铅浓度与关于行为、家庭习惯、饮食、父母吸烟和职业、水中铅测量以及交通流量的访谈数据进行了比较。父母吸烟、孩子在家庭中的排行、性别以及家中罐头食品的消费量解释了血铅变异的20%。
