Department of Pharmacy, The Second People's Hospital of Nanning City, The Third Affiliated Hospital of Guangxi Medical University, Guangxi, Nanning 530031, PR China.
Food Chem Toxicol. 2013 Oct;60:341-7. doi: 10.1016/j.fct.2013.07.077. Epub 2013 Aug 6.
Diabetes is a chronic disease characterized by the metabolic disorder in specific tissues. Our present study was designed to assess the potential benefits of puerarin (PR) on hypoglycemic and hypolipemic effects in diabetic mice induced by streptozotocin (STZ). The results achieved from these experiments showed that glycemia in STZ-diabetogenic mice were significantly reduced following the PR administration, while serum insulin concentration was increased. In addition, PR contributed to improving the dyslipidemia conditions. Histopathological examination indicated that the STZ-lesioned pancreas tissue in PR-administrated mice was effectively alleviated. Meanwhile, intrapancreatic protein levels of insulin receptor substrate-1 (IRS-1) and insulin-like growth factor-1 (IGF-1) were up-regulated, respectively. On the other hand, endogenous mRNA levels of skeletal muscle insulin receptor (InsR) and peroxisome proliferators-activated receptor α (PPARα) were increased after administration of PR. Taken together, these findings reveal that puerarin effectively exerts the hypoglycemic and hypolipemic roles, which its potential anti-diabetic activity is associated with elevating insulin expression and maintaining metabolic homoeostasis in STZ-diabetogenic mice.
糖尿病是一种以特定组织代谢紊乱为特征的慢性疾病。我们目前的研究旨在评估葛根素（PR）对链脲佐菌素（STZ）诱导的糖尿病小鼠降血糖和降血脂作用的潜在益处。这些实验的结果表明，PR 给药后 STZ 致糖尿病小鼠的血糖明显降低，而血清胰岛素浓度升高。此外，PR 有助于改善血脂异常状况。组织病理学检查表明，PR 给药组 STZ 损伤的胰腺组织得到了有效缓解。同时，胰腺内胰岛素受体底物-1（IRS-1）和胰岛素样生长因子-1（IGF-1）的蛋白水平分别上调。另一方面，PR 给药后骨骼肌胰岛素受体（InsR）和过氧化物酶体增殖物激活受体α（PPARα）的内源性 mRNA 水平增加。总之，这些发现表明葛根素能有效发挥降血糖和降血脂作用，其潜在的抗糖尿病活性与其提高胰岛素表达和维持 STZ 致糖尿病小鼠代谢平衡有关。
