Department of Public Health and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Int J Tuberc Lung Dis. 2013 Sep;17(9):1229-34. doi: 10.5588/ijtld.12.0984.
To determine whether there were any defects in the presentation of the Mycobacterium tuberculosis antigen by monocytes from patients with tuberculosis (TB) and the role of vitamin D in the defence against M. tuberculosis.
A prospective study aimed at analysing the presentation of the M. tuberculosis antigen by monocytes and the response to vitamin D treatment in three groups of participants: 1) those with active TB, 2) those with healed TB and 3) those with frequent TB contact.
The antigen presentation ability of monocytes of persons in the frequent contact group was significantly higher than that of the active TB and healed TB groups. There was no difference between patients with active and healed TB. In addition, 1,25(OH)2D3 increased the presentation of mycobacterial antigens by monocytes from participants with frequent TB contact, but not those with active or healed TB.
Patients with active and healed TB exhibit defective M. tuberculosis presentation in monocytes. The administration of vitamin D did not correct this defect in monocytes from participants with active or healed TB, but could increase antigen presentation by monocytes in participants with frequent TB contact.
确定结核分枝杆菌（TB）患者单核细胞中结核分枝杆菌抗原的呈递是否存在缺陷，以及维生素 D 在抵御结核分枝杆菌中的作用。
一项前瞻性研究旨在分析三组参与者（1）活动性 TB 患者，2）治愈性 TB 患者和 3）TB 密切接触者）中单核细胞对结核分枝杆菌抗原的呈递以及对维生素 D 治疗的反应：1）TB 密切接触者，2）活动性 TB 患者，3）治愈性 TB 患者。
频繁接触组的单核细胞的抗原呈递能力明显高于活动性 TB 和治愈性 TB 组。活动性 TB 患者和治愈性 TB 患者之间无差异。此外，1,25(OH)2D3 增加了来自 TB 密切接触者的单核细胞对分枝杆菌抗原的呈递，但对活动性或治愈性 TB 患者的单核细胞无影响。
活动性 TB 和治愈性 TB 患者的单核细胞中存在结核分枝杆菌呈递缺陷。维生素 D 的给药不能纠正活动性或治愈性 TB 患者单核细胞中的这种缺陷，但可以增加 TB 密切接触者单核细胞的抗原呈递。
