Zeng Junli, Wu Guannan, Yang Wen, Gu Xiaoling, Liang Wenjun, Yao Yanwen, Song Yong
Department of Respiratory Medicine, Jinling Hospital, Southern Medical University (Guangzhou), Nanjing, China 210002.
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China 210002.
PLoS One. 2015 May 4;10(5):e0126014. doi: 10.1371/journal.pone.0126014. eCollection 2015.
Low serum Vitamin D is considered to be associated with tuberculosis while the "dangerous" level was not clear. The aim of this study was to identify the association between tuberculosis and serum Vitamin D levels via synthesis of available evidence.
A search of EMBASE, Medline, ISI Web of knowledge, and Pubmed was conducted. The number of subjects of tuberculosis and no-tuberculosis groups in four Vitamin D range. Meta-analyses were performed and presented by odds ratios (ORs) and corresponding 95% confidence intervals (CIs).
A total of 15 studies involving 1440 cases and 2558 controls were included. A significantly increased risk of tuberculosis was found in two ranges: ≤ 12.5 nmol/L: pooled OR = 4.556, 95% CI = 2.200-9.435; 13-25 nmol/L: pooled OR = 3.797, 95% CI = 1.935-7.405. No statistically significant risk of tuberculosis was found in the range of 26-50 nmol/L (pooled OR = 1.561, 95% CI =0.997-2.442). In range 51-75 nmol/L, no positive association was found (pooled OR =1.160, 95% CI = 0.708-1.900).
This study found that a serum Vitamin D level ≤ 25 nmol/L was significantly associated with an increased risk of tuberculosis while the range of 51-75 nmol/L was not. The range 26-50nmol/L posed potential high tuberculosis risk. Future large-scale, well-designed studies are needed to verify these results.
低血清维生素D被认为与结核病有关，但其“危险”水平尚不清楚。本研究的目的是通过综合现有证据确定结核病与血清维生素D水平之间的关联。
检索了EMBASE、Medline、ISI Web of knowledge和Pubmed。统计四个维生素D范围内结核病组和非结核病组的受试者数量。进行荟萃分析，并以比值比（OR）和相应的95%置信区间（CI）表示。
共纳入15项研究，涉及1440例病例和2558例对照。在两个范围内发现结核病风险显著增加：≤12.5 nmol/L：合并OR = 4.556，95% CI = 2.200 - 9.435；13 - 25 nmol/L：合并OR = 3.797，95% CI = 1.935 - 7.405。在26 - 50 nmol/L范围内未发现结核病的统计学显著风险（合并OR = 1.561，95% CI = 0.997 - 2.442）。在51 - 75 nmol/L范围内未发现正相关（合并OR = 1.160，95% CI = 0.708 - 1.900）。
本研究发现，血清维生素D水平≤25 nmol/L与结核病风险增加显著相关，而51 - 75 nmol/L范围则不然。26 - 50 nmol/L范围存在潜在的高结核病风险。未来需要大规模、精心设计的研究来验证这些结果。
