Zhang Qi, Qian Yun, Jin Zi-Yi, Dong Mei-hua, Han Ren-qiang, Zhou Jin-yi, Zhao Jin-kou, Zhang Zuo-feng, Wu Ming
Department of Epidemiology and Statistics, School of Public Health, Southeast University, Nanjing 210009, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2013 Apr;47(4):358-62.
To estimate the association between overweight, obesity and the risk of breast cancer in Chinese female population.
Literatures published in China and abroad about overweight, obesity and breast cancer risk among Chinese females were searched. We used "breast cancer", "overweight", "obesity", "weight", "body mass index" and "risk factors" as keywords, to retrieve papers in Chinese literature databases including CNKI, Wanfang and Weipu database. The same strategy was used to retrieve English papers in English literature database including Embase database, PubMed, Science Direct, Elsevier and Cochrane database, supplemented by literature tracing method. Time range was from the founding of each database to April 2012. A total of 124 research papers were collected. Using Stata11.2 software, meta-analysis was conducted, combined odds ratio (OR) and 95% confidence interval (CI) were calculated to estimate the associations between overweight, obesity and the risk of breast cancer in Chinese female population.
Eighteen studies were included in meta-analysis, among them 12 studies were in Chinese and 6 were in English, with a number of 7217 cases and 81 605 controls. Results showed a 7.7% increased risk of breast cancer among overweight or obesity women (OR = 1.08, 95%CI: 1.04 - 1.12). Compared with normal BMI women, the OR (95%CI) of overweight or obesity women were 1.07 (1.03 - 1.11) and 1.56 (1.29 - 1.84) before and after the adjustment of menopausal status.
Overweight, obesity may be important risk factors of breast cancer in Chinese female population. The intervention and control activities may reduce the risk of breast cancer at population level.
评估中国女性人群中超重、肥胖与乳腺癌风险之间的关联。
检索国内外发表的关于中国女性超重、肥胖与乳腺癌风险的文献。我们使用“乳腺癌”“超重”“肥胖”“体重”“体重指数”和“危险因素”作为关键词，在中国文献数据库（包括CNKI、万方和维普数据库）中检索论文。采用相同策略在英文文献数据库（包括Embase数据库、PubMed、ScienceDirect、爱思唯尔和考克兰数据库）中检索英文论文，并辅以文献追溯法。时间范围为各数据库建库至2012年4月。共收集到124篇研究论文。使用Stata11.2软件进行荟萃分析，计算合并比值比（OR）和95%置信区间（CI），以评估中国女性人群中超重、肥胖与乳腺癌风险之间的关联。
18项研究纳入荟萃分析，其中12项为中文研究，6项为英文研究，共7217例病例和81605例对照。结果显示，超重或肥胖女性患乳腺癌的风险增加7.7%（OR = 1.08，95%CI：1.04 - 1.12）。与正常体重指数女性相比，调整绝经状态前后，超重或肥胖女性的OR（95%CI）分别为1.07（1.03 - 1.11）和1.56（1.29 - 1.84）。
超重、肥胖可能是中国女性人群患乳腺癌的重要危险因素。干预和控制措施可能会在人群层面降低乳腺癌风险。
