Yu M W, Chen C J, Wang C J, Tong S L, Tien M, Lee T Y, Lue H C, Huang F Y, Lan C C, Yang K H
Institute of Public Health, National Taiwan University College of Medicine, Republic of China.
Acta Genet Med Gemellol (Roma). 1990;39(1):99-108. doi: 10.1017/s0001566000005614.
In order to examine the chronological changes in genetic variance and heritability of arterial systolic and diastolic blood pressure (SBP and DBP of Chinese infants in Taiwan, a total of 339 same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on placentation and 12 red blood cell antigens, 274 monozygotic (MZ) and 65 dizygotic (DZ) twin pairs were identified and followed up to the age of one year. Both SBP and DBP were measured by Doppler blood pressure monitor. Within-pair mean squares of SBP and DBP were consistently smaller in MZ than DZ twins at ages one month and over. The findings remained unchanged after the adjustment for the effects of age, sex, gestational age, placentation and physical state during blood pressure measurement. Falconer's heritability indices for adjusted SBP and DBP at ages two months and over ranged from 0.29 to 0.55 and from 0.27 to 0.45, respectively. The study indicates an important genetic influence on blood pressure during infancy.
为了研究台湾地区中国婴儿动脉收缩压和舒张压（SBP和DBP）遗传方差和遗传率随时间的变化，对台北市四家主要综合教学医院出生的339对同性双胎新生儿进行了研究。根据胎盘形成情况和12种红细胞抗原，确定了274对单卵双胎（MZ）和65对双卵双胎（DZ），并随访至一岁。SBP和DBP均采用多普勒血压监测仪测量。在一个月及以上各年龄组中，MZ双胎SBP和DBP的组内均方始终小于DZ双胎。在对年龄、性别、孕周、胎盘形成情况和血压测量时的身体状态等因素进行校正后，研究结果保持不变。两个月及以上各年龄组校正后SBP和DBP的Falconer遗传率指数分别为0.29至0.55和0.27至0.45。该研究表明，婴儿期血压受遗传因素的重要影响。
