Carmelli D, Ward M M, Reed T, Grim C E, Harshfield G A, Fabsitz R R
Health Sciences Program, SRI International, Menlo Park, CA 94025.
Am J Hypertens. 1991 Mar;4(3 Pt 1):239-44. doi: 10.1093/ajh/4.3.239.
The purpose of the present investigation was to examine the genetic contributions to cardiovascular reactivity in an adult cohort of male twins. A total of 47 monozygotic (MZ) twin pairs and 54 dizygotic (DZ) twin pairs, aged 59 to 69 years, were laboratory tested at four sites as part of the third examination of the National Heart, Lung, and Blood Institute Twin Study. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were recorded during two tasks, a mental arithmetic task involving serial subtraction and the cold pressor test. Significant cardiovascular responsivity was observed during both tasks as measured by substantial elevations in SBP, DBP, and HR from resting periods to task periods. Heritability estimates were statistically significant for SBP and DBP but not HR levels during pretask baseline periods and during both tasks. Genetic variance was maintained for blood pressure reactivity to the mental arithmetic task after adjustments for baseline and performance. No genetic variance for SBP or DBP reactivity to the cold pressor test was evident.
本研究的目的是在成年男性双胞胎队列中检验心血管反应性的遗传贡献。作为美国国立心肺血液研究所双胞胎研究第三次检查的一部分，共有47对同卵（MZ）双胞胎和54对异卵（DZ）双胞胎，年龄在59至69岁之间，在四个地点进行了实验室测试。在两项任务中记录收缩压（SBP）、舒张压（DBP）和心率（HR），一项是涉及连续减法的算术任务，另一项是冷加压试验。从休息期到任务期，SBP、DBP和HR显著升高，表明在两项任务中均观察到显著的心血管反应性。在任务前基线期和两项任务期间，SBP和DBP的遗传度估计具有统计学意义，但HR水平无统计学意义。在对基线和表现进行调整后，血压对算术任务的反应性的遗传方差得以维持。冷加压试验中SBP或DBP反应性无明显遗传方差。
