Smith T W, Turner C W, Ford M H, Hunt S C, Barlow G K, Stults B M, Williams R R
Health Psychol. 1987;6(3):209-20. doi: 10.1037//0278-6133.6.3.209.
The purpose of the present investigation was to examine possible genetic contributions to cardiovascular reactivity by contrasting patterns of association in 82 monozygotic (MZ) and 88 dizygotic (DZ) adult male twin pairs (age range = 21 to 61 years, M = 35 years). Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were recorded during baseline and during a mental arithmetic task (i.e., serial subtraction). The task produced significant elevations in all three cardiovascular measures (i.e., 10 mmHg SBP, 8 mmHg DBP, and 6 bpm HR, respectively). Levels of SBP and DBP reactivity were significantly correlated in MZ pairs but not in DZ pairs. Statistical tests suggest a heritability estimate of about 50% that was marginally significantly for SBP and DBP changes during the task. There was no indication of a genetic influence on HR reactivity. Resting level and static task period measures of SBP, DBP, and HR demonstrated statistically significant heritability estimates of 60% to 80%.
本研究的目的是通过对比82对同卵（MZ）成年男性双胞胎和88对异卵（DZ）成年男性双胞胎（年龄范围 = 21至61岁，平均年龄 = 35岁）的关联模式，来检验心血管反应性可能的遗传贡献。在基线期和心算任务（即连续减法）期间记录收缩压（SBP）、舒张压（DBP）和心率（HR）。该任务使所有三项心血管指标均显著升高（即SBP升高10 mmHg、DBP升高8 mmHg、HR升高6次/分钟）。SBP和DBP反应性水平在MZ双胞胎对中显著相关，但在DZ双胞胎对中不相关。统计检验表明，任务期间SBP和DBP变化的遗传率估计约为50%，略具显著性。没有迹象表明遗传对HR反应性有影响。SBP、DBP和HR的静息水平和静态任务期测量结果显示，遗传率估计具有统计学显著性，为60%至80%。
