Department of Surgery, Medical School of the Federal University of Ceará, Rua Profesor Costa Mendes no. 1608, Rodolfo Teófilo, Fortaleza - CE, Brazil.
Braz J Otorhinolaryngol. 2013 Aug;79(4):480-6. doi: 10.5935/1808-8694.20130086.
Cystic Fibrosis (CF) results from mutation in the transmembrane conductance regulator gene, responsible for controlling secretory processes. The upper airways (UA) are usually involved in the form of chronic pansinusitis.
To evaluate UA changes in patients with CF and to establish the correlations between sinonasal CT and endoscopic endonasal findings and disease severity.
Cross-sectional and prospective study with 20 patients older than 5 years with CF, assessing the Shwachman-Kulczycki (S-K) score, paranasal sinus tomography (CT) (Lund-Mackay score) and nasal endoscopy (Meltzer score).
CT scan alterations were observed in 94% of cases. Endoscopic alterations findings in the upper airways were found in 10 patients. Nasal polyps were found in 3 patients (15%). There was a correlation between the intensity of changes on the CT and S-K score (p = 0.0097), and between endoscopic findings and S-K score (p = 0.0318). There was a positive correlation between the presence of chronic colonization and endoscopic findings (p = 0.0325), which was not observed on the CT (p = 0.2941).
There is an inverse correlation between the S-K clinical score and nasal endoscopy and CT findings. Therefore, patients who are clinically more severe according to the S-K score have greater UA involvement.
评估囊性纤维化（CF）患者的上呼吸道（UA）变化，并确定鼻旁窦 CT 和鼻内镜检查结果与疾病严重程度之间的相关性。
这是一项具有 20 名年龄大于 5 岁 CF 患者的横断面和前瞻性研究，评估 Shwachman-Kulczycki（S-K）评分、副鼻窦体层摄影术（CT）（Lund-Mackay 评分）和鼻内镜（Meltzer 评分）。
94%的病例观察到 CT 扫描改变。10 例患者发现上呼吸道内镜改变。3 例患者（15%）发现鼻息肉。CT 上的变化强度与 S-K 评分之间存在相关性（p=0.0097），内镜检查结果与 S-K 评分之间存在相关性（p=0.0318）。慢性定植的存在与内镜检查结果之间存在正相关（p=0.0325），但在 CT 上未观察到这种相关性（p=0.2941）。
S-K 临床评分与鼻内镜和 CT 检查结果呈负相关。因此，根据 S-K 评分，临床症状更严重的患者 UA 受累更大。
