Dipartimento di Farmacia, Università di Pisa, Pisa, Italy.
Planta Med. 2013 Sep;79(14):1341-7. doi: 10.1055/s-0033-1350648. Epub 2013 Aug 8.
Four new clerodane diterpenes (1-4) and one new phenylpropanoid (5) have been isolated from Clerodendrum splendens aerial parts, together with nine known compounds. Their structures were determined by spectroscopic and spectrometric analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 4 was determined by Snatzke's method. Antiproliferative activity of diterpenes in HeLa cells was also evaluated. The IC50 values were 98 ± 11 µM for 3 and 101 ± 8 µM for 1, respectively.
从臭牡丹的地上部分分离得到了 4 个新的 clerodane 二萜（1-4）和 1 个新的苯丙素（5），以及 9 个已知化合物。通过光谱和光谱分析以及化学方法确定了它们的结构。通过 Snatzke 法确定了 4 中 15,16-二醇部分的绝对构型。还评估了二萜在 HeLa 细胞中的抗增殖活性。3 的 IC50 值为 98 ± 11 µM，1 的 IC50 值为 101 ± 8 µM。
