Dai Sheng-Jun, Sun Jing-Yong, Ren Yan, Liu Ke, Shen Li
School of Pharmaceutical Science, Yantai University, Yantai, People's Republic of China.
Planta Med. 2007 Sep;73(11):1217-20. doi: 10.1055/s-2007-990215. Epub 2007 Aug 31.
Four new ENT-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures were elucidated by chemical methods and spectral analyses. in vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.1-7.2 microM.
从半枝莲（唇形科）全草中分离出四种新的对映-贝壳杉烷二萜类化合物。通过化学方法和光谱分析阐明了它们的结构。在体外，这四种新化合物对三种人类癌细胞系（HONE-1鼻咽癌、KB口腔表皮样癌和HT29结肠癌细胞）显示出显著的细胞毒活性，IC50值在3.1 - 7.2微摩尔范围内。
