还有人应该服用80毫克的辛伐他汀吗？
Should anyone still be taking simvastatin 80 mg?
作者信息
Tayal Upasana, Carroll Richard
机构信息
Barnet Hospital, London, UK.
出版信息
BMJ Case Rep. 2013 Aug 8;2013:bcr2013200415. doi: 10.1136/bcr-2013-200415.
Abstract
A 64-year-old woman who previously suffered myalgia with lower dose simvastatin was given just one high dose of simvastatin and developed rhabdomyolysis. This was a potentially life-threatening complication. Fortunately she recovered with conservative management and did not require haemofiltration. This case reminds us of the risks of statins and the caution that needs to be exercised when prescribing these medications to patients with a history of intolerances.
摘要
一名64岁女性，之前服用低剂量辛伐他汀时曾出现肌痛，此次仅服用了一剂高剂量辛伐他汀便发生了横纹肌溶解症。这是一种可能危及生命的并发症。幸运的是，她通过保守治疗康复，无需进行血液滤过。该病例提醒我们他汀类药物存在风险，在给有不耐受史的患者开这些药物时需要谨慎。
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Daily and intermittent rosuvastatin 5 mg therapy in statin intolerant patients: an observational study.每日和间断性使用 5 毫克瑞舒伐他汀治疗不耐受他汀类药物的患者：一项观察性研究。
Curr Med Res Opin. 2012 Mar;28(3):371-8. doi: 10.1185/03007995.2012.657302. Epub 2012 Feb 7.
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Statin-associated rhabdomyolysis: is there a dose-response relationship?他汀类药物相关性横纹肌溶解症：是否存在剂量反应关系？
Can J Cardiol. 2011 Mar-Apr;27(2):146-51. doi: 10.1016/j.cjca.2010.12.024.
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Lancet. 2010 Nov 13;376(9753):1658-69. doi: 10.1016/S0140-6736(10)60310-8. Epub 2010 Nov 8.
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