Carpenter Alexis W, Reighard Katelyn P, Saavedra Joseph E, Schoenfisch Mark H
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;
Biomater Sci. 2013 May 1;1(5):456-459. doi: 10.1039/C3BM00153A.
O-protected -diazeniumdiolate-based silanes were grafted onto mesoporous silica nanoparticles to yield a scaffold with an NO payload of 2.4 μmol NO/mg and NO release half-life of 23 d. Reduced (3-log) viable adhesion was observed for NO-releasing dental restorative materials modified with these particles relative to controls.
将基于O-保护的重氮二醇盐的硅烷接枝到介孔二氧化硅纳米颗粒上，以产生一种支架，其NO负载量为2.4 μmol NO/mg，NO释放半衰期为23天。相对于对照，观察到用这些颗粒改性的释放NO的牙科修复材料的活细胞粘附减少（3个对数）。
