Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Sci Rep. 2018 Jan 17;8(1):895. doi: 10.1038/s41598-018-19166-8.
Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control. Herein we demonstrate the co-assembly of an antimicrobial drug (octenidine dihydrochloride, OCT), and silica, to form highly-loaded (35% wt.) OCT-silica nanocomposite spheres of 500 nm diameter. Drug release significantly outlasted conventional OCT-loaded mesoporous silica, closely fit Higuchi models of diffusive release, and was visualized via electron microscopy. Extension of this concept to the broad collection of self-assembling drugs grants biomedical community a powerful tool for synthesizing drug-loaded inorganic nanomaterials from the bottom-up.
用于骨科修复和牙科修复的生物材料中的抗菌药物释放可以防止生物膜的生长和龋齿的形成。药物掺入的载体将受益于长期药物储存、控制释放和结构稳定性。介孔硅通过硅和表面活性剂模板的共组装合成，是一种理想的药物封装支架，在释放时保持结构完整性。然而，通过浓度梯度扩散将药物常规负载到介孔硅孔中会限制总载药量、浓度均匀性和药物释放控制。在这里，我们展示了一种抗菌药物（盐酸奥替尼啶，OCT）和二氧化硅的共组装，形成了高负载量（35wt%）的 500nm 直径的 OCT-二氧化硅纳米复合球。药物释放明显超过了传统的负载介孔硅的 OCT，非常符合 Higuchi 扩散释放模型，并通过电子显微镜进行了可视化。将这一概念扩展到广泛的自组装药物，为生物医学界提供了一种从下到上合成载药无机纳米材料的强大工具。
