Department of Clinical Nutrition, The First Hospital of China Medical University, Shenyang, 110001, China.
Department of Immunization, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, 214023, China.
J Cancer Res Clin Oncol. 2024 Jul 9;150(7):344. doi: 10.1007/s00432-024-05866-4.
Colorectal cancer (CRC) is a common malignancy that affects adults worldwide, causing a high disease burden. Few studies have examined the relationship between body composition (BC) measures and the prevalence of CRC. Our purpose was to investigate the relationship between pertinent BC indicators and CRC.
Bioelectrical impedance analysis, laboratory test results, face-to-face questionnaire investigation, and nutritional risk assessment (Nutritional Risk Screening 2002 and Patient-Generated Subjective Global Assessment) were used in this case-control study. Bioelectrical impedance analysis in the case group was performed prior to antitumor therapy/surgery.
From June 2018 to January 2019, a total of 303 cases and 286 controls were included. The results showed that low body fat percentage (BFP) and high visceral adiposity index (VAI) groups had a higher risk of developing CRC in comparison to the normal BFP and normal VAI groups. The risk of CRC decreased with the increase of BFP. The group with a normal BC had a lower risk of developing CRC compared to those with a greater VAI and a lower BFP, as indicated by the results of the pairwise and total combinations of VAI, fat-free mass index (FFMI), and BFP. Additionally, FFMI and VAI had positive correlations with prealbumin, serum albumin, and nutritional risk scores.
Low BFP and high VAI are associated with higher CRC risk. FFMI and VAI are positively correlated with prealbumin, serum albumin, and nutritional risk scores in CRC patients.
结直肠癌（CRC）是一种常见的恶性肿瘤，影响全球成年人，造成了很高的疾病负担。很少有研究探讨身体成分（BC）指标与 CRC 患病率之间的关系。我们的目的是研究相关 BC 指标与 CRC 之间的关系。
本病例对照研究采用了生物电阻抗分析、实验室检测结果、面对面问卷调查和营养风险评估（2002 年营养风险筛查和患者主观整体评估）。病例组在抗肿瘤治疗/手术前进行了生物电阻抗分析。
2018 年 6 月至 2019 年 1 月，共纳入 303 例病例和 286 例对照。结果显示，低体脂百分比（BFP）和高内脏脂肪指数（VAI）组发生 CRC 的风险高于正常 BFP 和正常 VAI 组。BFP 增加，CRC 风险降低。与高 VAI 和低 BFP 相比，正常 BC 组发生 CRC 的风险较低，这表明 VAI、去脂体重指数（FFMI）和 BFP 的两两和总组合结果。此外，FFMI 和 VAI 与前白蛋白、血清白蛋白和营养风险评分呈正相关。
低 BFP 和高 VAI 与较高的 CRC 风险相关。CRC 患者的 FFMI 和 VAI 与前白蛋白、血清白蛋白和营养风险评分呈正相关。
