Ito K, Hayasaki M, Tamaya T
Department of Obstetrics and Gynecology, School of Medicine, Gifu University, Japan.
Antimicrob Agents Chemother. 1990 Jun;34(6):1160-4. doi: 10.1128/AAC.34.6.1160.
Many cephalosporin antibiotics have recently been invented and attempts have been made to use them clinically. The choice of which of these drugs should be used has been difficult in gynecology. The efficacies of these drugs depend on their antibacterial spectra, potencies, and concentrations in tissues. This study was designed to investigate the pharmacokinetics of various cephem antibiotics in the exudate of the retroperitoneal space that is formed after radical hysterectomy and pelvic lymphadenectomy. These cephem antibiotics were cefoxitin, cefotiam, cefotetan, cefpiramide, cefminox, cefotaxime, ceftizoxime, cefoperazone, cefmenoxime, cefbuperazone, ceftazidime, cefpimizole, flomoxef, and cefuzonam. The maximum concentrations after administration of a 1-g dose in the exudate of the pelvic retroperitoneal space were 37.9 micrograms/ml with cefminox, 30.3 micrograms/ml with cefpimizole, 21.6 micrograms/ml with flomoxef, 21.5 micrograms/ml with ceftazidime, and 17.6 micrograms/ml with cefbuperazone, which were relatively high. When selecting antibiotics for prophylactic use against infections in the retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy, on the basis of drug transfer, flomoxef, cefminox, cefbuperazone, ceftazidime, and cefpimizole were considered to be the drugs of first choice at a dose of 1 g.
最近发明了许多头孢菌素抗生素，并已尝试将其用于临床。在妇科领域，选择使用哪种此类药物一直很困难。这些药物的疗效取决于它们的抗菌谱、效力以及在组织中的浓度。本研究旨在调查各种头孢烯抗生素在根治性子宫切除术和盆腔淋巴结清扫术后形成的腹膜后间隙渗出液中的药代动力学。这些头孢烯抗生素包括头孢西丁、头孢替安、头孢替坦、头孢匹胺、头孢米诺、头孢噻肟、头孢唑肟、头孢哌酮、头孢甲肟、头孢布烯、头孢他啶、头孢咪唑、氟氧头孢和头孢唑南。在盆腔腹膜后间隙渗出液中给予1g剂量后，头孢米诺的最高浓度为37.9微克/毫升，头孢咪唑为30.3微克/毫升，氟氧头孢为21.6微克/毫升，头孢他啶为21.5微克/毫升，头孢布烯为17.6微克/毫升，这些浓度相对较高。在选择用于根治性子宫切除术和盆腔淋巴结清扫术后预防腹膜后间隙感染的抗生素时，基于药物转运情况，氟氧头孢、头孢米诺、头孢布烯、头孢他啶和头孢咪唑被认为是1g剂量时的首选药物。
