Department of Clinical Nursing Science, Yonsei University College of Nursing, Nursing Policy and Research Institute, Biobehavioral Research Center, Seoul 120-752, Korea.
Endocr J. 2013;60(11):1269-73. doi: 10.1507/endocrj.ej13-0207. Epub 2013 Aug 9.
Sirtuin1 (SIRT1) is activated during calorie restriction and appears to be related to energy balance through glucose or lipid metabolism and insulin signaling. These findings suggest that SIRT1 may play a role in the pathophysiology of visceral obesity. Therefore, we investigated the relationship between SIRT1 gene expression in circulating peripheral blood mononuclear cells (PBMCs) and abdominal visceral adiposity as measured by computed tomography. We recruited 43 men and women without history of diabetes or cardiovascular disease Biomarkers of metabolic disease and body composition by computed tomography were assessed. SIRT1 gene expression was determined using isolated PBMCs. SIRT1 expression levels negatively correlated with body mass index, waist circumference, abdominal visceral fat area, and homeostasis model of assessment of insulin resistance (HOMA-IR) and positively correlated with adiponectin levels. Results of step-wise multiple regression analysis revealed that abdominal visceral fat area and HOMA-IR were independently associated with SIRT1 expression. The significant association between abdominal visceral fat accumulation and SIRT1 gene expression in PBMCs suggests that SIRT1 may be a new therapeutic target for the prevention of disease related to obesity, especially visceral obesity.
Sirtuin1（SIRT1）在热量限制期间被激活，似乎通过葡萄糖或脂质代谢和胰岛素信号与能量平衡有关。这些发现表明 SIRT1 可能在内脏肥胖的病理生理学中发挥作用。因此，我们研究了通过计算机断层扫描测量的循环外周血单个核细胞（PBMC）中 SIRT1 基因表达与腹部内脏肥胖之间的关系。我们招募了 43 名无糖尿病或心血管疾病病史的男性和女性，通过计算机断层扫描评估代谢疾病和身体成分的生物标志物。使用分离的 PBMC 确定 SIRT1 基因表达。SIRT1 表达水平与体重指数、腰围、腹部内脏脂肪面积和稳态模型评估的胰岛素抵抗（HOMA-IR）呈负相关，与脂联素水平呈正相关。逐步多元回归分析的结果表明，腹部内脏脂肪面积和 HOMA-IR 与 SIRT1 表达独立相关。腹部内脏脂肪堆积与 PBMC 中 SIRT1 基因表达之间的显著关联表明，SIRT1 可能是预防与肥胖相关疾病的新治疗靶点，尤其是内脏肥胖。
