Gatzioufas Z, Seitz B
Klinik für Augenheilkunde, Universitätsklinikum Genf HUG, Rue Alcide-Jentzer 22, 1211, Genf, Schweiz.
Ophthalmologe. 2013 Sep;110(9):810, 812-7. doi: 10.1007/s00347-013-2818-x.
Keratoconus is a bilateral, progressive, non-inflammatory corneal degeneration characterized by a conical protrusion of the cornea which leads to marked corneal thinning thereby inducing severe visual impairment due to increasingly irregular astigmatism. Current corneal imaging technology provides an accurate anatomical and topographical analysis of the cornea which is the 'gold standard for the diagnosis of keratoconus and preoperative screening in refractive surgery. Until recently evaluation of corneal biomechanics was feasible only in vitro as the technology required for in vivo analysis was not available. However, in recent years methods have been developed which enable an accurate in vivo analysis of corneal biomechanics thereby enhancing the early detection of keratoconus and improving the safety profile of corneal refractive procedures.
圆锥角膜是一种双侧性、进行性、非炎症性角膜变性，其特征是角膜呈圆锥形突出，导致角膜明显变薄，进而由于散光日益不规则而引起严重视力损害。目前的角膜成像技术可对角膜进行准确的解剖学和地形图分析，这是诊断圆锥角膜和屈光手术术前筛查的“金标准”。直到最近，由于缺乏用于体内分析的技术，角膜生物力学评估仅在体外可行。然而，近年来已开发出一些方法，能够对角膜生物力学进行准确的体内分析，从而加强圆锥角膜的早期检测，并改善角膜屈光手术的安全性。
