Department of Imaging, Biomechanics and Mathematical Modeling Solutions, Narayana Nethralaya, Bangalore, Karnataka, India.
Indian J Ophthalmol. 2013 Aug;61(8):392-3. doi: 10.4103/0301-4738.116057.
Keratoconus (KC) is progressive disease of corneal thinning, steepening and collagen degradation. Biomechanics of the cornea is maintained by the intricate collagen network, which is responsible for its unique shape and function. With the disruption of this collagen network, the cornea loses its shape and function, resulting in progressive visual degradation. While KC is essentially a stromal disease, there is evidence that the epithelium undergoes significant thinning similar to the stroma. Several topographical approaches have been developed to detect KC early. However, it is now hypothesized that biomechanical destabilization of the cornea may precede topographic evidence of KC. Biomechanics of KC has been investigated only to a limited extent due to lack of in vivo measurement techniques and/or devices. In this review, we focus on recent work performed to characterize the biomechanical characteristics of KC.
圆锥角膜（KC）是一种进行性的角膜变薄、变陡和胶原降解疾病。角膜的生物力学由复杂的胶原网络维持，这是其独特形状和功能的原因。随着这种胶原网络的破坏，角膜失去了形状和功能，导致视力逐渐下降。虽然 KC 本质上是一种基质疾病，但有证据表明上皮层也会像基质一样发生明显变薄。已经开发了几种地形学方法来早期发现 KC。然而，现在假设角膜的生物力学不稳定性可能先于 KC 的地形学证据。由于缺乏体内测量技术和/或设备，对 KC 的生物力学的研究还很有限。在这篇综述中，我们重点介绍了最近为表征 KC 的生物力学特征而进行的工作。
