Division of neurology, Department of Medicine, Queen Mary Hospital, The university of Hong Kong, Hong Kong SaR, China.
J Nutr Health Aging. 2013 Jul;17(7):600-4. doi: 10.1007/s12603-013-0043-6.
To investigate the effects of garlic on endothelial function in patients with ischemic stroke (ISS).
Cross-sectional study.
125 Chinese patients with prior ISS due to athero-thrombotic disease were recruited from the outpatient clinics during July 2005 to December 2006.
Daily allium vegetable intake (including garlic, onions, Chinese chives and shallots) was ascertained by means of a validated food frequency questionnaire for Chinese and brachial artery flow-mediated dilatation (FMD) was measured using high-resolution ultrasound in all subjects.
The mean age of the study population was 65.9±11.1 years and 69% were males. Mean allium vegetable intake and garlic intake of the study population was 7.5±12.7g/day and 2.9±8.8g/day respectively. Their mean FMD was 2.6±2.3%. Daily intake of total allium vegetable (r=0.36, P<0.01) and garlic (r=0.34, P<0.01) significantly correlated with FMD. Using the median daily allium intake as cut-off (3.37g/day), patients with a low allium intake <3.37g/day was noted to have a lower FMD compared to those with a normal allium intake (2.1±2.1% versus 3.0±2.4%, P<0.05). After adjusting for confounding factors, multi-variate analysis identified that daily allium vegetable (B=0.05, 95% confidence interval: 0.02, 0.09, P<0.01) and garlic (B=0.07, 95% confidence interval: 0.02, 0.12, P<0.01) intake, but not onions, Chinese chives and shallots were independent predictors for changes in FMD in patients with ISS.
Daily garlic intake is an independent predictor of endothelial function in patients with ISS and may play a role in the secondary prevention of atherosclerotic events.
研究大蒜对缺血性脑卒中（ISS）患者内皮功能的影响。
横断面研究。
2005 年 7 月至 2006 年 12 月期间，从门诊招募了 125 名因动脉粥样硬化血栓形成疾病而发生 ISS 的中国患者。
通过经过验证的中国食物频率问卷确定每日食用大蒜等葱属蔬菜的情况，并使用高分辨率超声测量所有受试者的肱动脉血流介导的扩张（FMD）。
研究人群的平均年龄为 65.9±11.1 岁，69%为男性。研究人群的平均葱属蔬菜摄入量和大蒜摄入量分别为 7.5±12.7g/天和 2.9±8.8g/天。他们的平均 FMD 为 2.6±2.3%。总葱属蔬菜（r=0.36，P<0.01）和大蒜（r=0.34，P<0.01）的每日摄入量与 FMD 显著相关。以中位数每日葱属摄入量作为切点（3.37g/天），发现低摄入量<3.37g/天的患者 FMD 低于正常摄入量的患者（2.1±2.1%与 3.0±2.4%，P<0.05）。在调整混杂因素后，多变量分析确定每日葱属蔬菜（B=0.05，95%置信区间：0.02，0.09，P<0.01）和大蒜（B=0.07，95%置信区间：0.02，0.12，P<0.01）的摄入量，但不是洋葱、韭菜和青葱，是 ISS 患者 FMD 变化的独立预测因子。
每日大蒜摄入量是 ISS 患者内皮功能的独立预测因子，可能在动脉粥样硬化事件的二级预防中发挥作用。
