Smith Rachel A, Wienke Sara, Coffman Donna L
Department of Communication Arts & Sciences and Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA, 16803, USA,
J Genet Couns. 2014 Apr;23(2):212-20. doi: 10.1007/s10897-013-9639-6. Epub 2013 Aug 11.
Couples often discuss genetic test results, and then manage their implications together. This interdependence can lead to common, shared experiences, similar intrapersonal processes to manage shared stressors, or interpersonal influences between spouses, leading to different outcomes. This study sought to reveal the intracouple, intrapersonal, and interpersonal influences of genetic stigma and negative feelings on spousal communication and perceived stress with 50 couples in which one spouse is a member of a genetic disease registry. The results were analyzed with dyadic analysis, including multilevel modeling. The findings showed that registered members and their spouses were not statistically different in their mean levels of perceived genetic stigma, negative feelings about alpha-1 antitrypsin deficiency (AATD), conversations with each other about the AATD test results, and their perceived stress. The findings also showed that their intracouple consistencies were not high, and their intrapersonal and interpersonal influences on communication and stress differed. The social implications of genetic research at the interpersonal level are discussed.
夫妻双方经常会讨论基因检测结果，然后共同应对其影响。这种相互依赖可能会导致共同的、共享的经历，处理共同压力源时类似的个人内部过程，或者配偶之间的人际影响，从而产生不同的结果。本研究旨在揭示基因污名和负面情绪对50对夫妻配偶沟通和感知压力的夫妻内部、个人内部及人际影响，其中一方配偶是遗传病登记处的成员。结果采用二元分析进行分析，包括多层次建模。研究结果表明，登记成员及其配偶在基因污名感知平均水平、对α-1抗胰蛋白酶缺乏症（AATD）的负面情绪、彼此关于AATD检测结果的对话以及他们的感知压力方面没有统计学差异。研究结果还表明，他们的夫妻内部一致性不高，并且他们在沟通和压力方面的个人内部及人际影响也有所不同。本文讨论了人际层面基因研究的社会影响。
