Department of Infectious Disease, the First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China.
J Med Virol. 2013 Nov;85(11):1893-9. doi: 10.1002/jmv.23649. Epub 2013 Aug 9.
Hepatitis B virus (HBV) infection and its associated liver diseases have characteristics of familial clustering in China. However, the reasons for this are not understood fully. To address this issue, the prevalence HBV infection and the characteristics of unfavorable prognoses in clustering of infection in families in northwest China were investigated. Families with clustering of infection and unfavorable prognoses were enrolled, and general information and serum samples were collected. The clinical features and sequelae of HBV infection were compared among the blood relatives (including the first-, second-, and third-degree blood relatives) and spouses using the chi-square test or Fisher's exact test. A total of 102 clusterings of infection families with unfavorable prognoses were interviewed. In the first-, second-, and third-degree blood relatives and spouses, the prevalences of cirrhosis of the liver were 29.2%, 11.9%, and 8.7%, respectively, while those of hepatocellular carcinoma (HCC) were 21.8%, 1.4%, and 4.3%, respectively (P<0.05). The mean ages of the onset of cirrhosis of the liver in the first-, second-, and third-degree blood relatives and spouses were 57 ± 9.91, 47 ± 9.96, 38 ± 10.35, and 57 ± 8.49 years, respectively, while the mean ages of the onset of HCC were 60 ± 7.92, 49 ± 8.57, 41 ± 3.54, and 50 ± 0 years, respectively, (P<0.05). The first-, second-, and third-degree blood relatives from clustering of infection in families with unfavorable prognoses had prevalences of cirrhosis or HCC in descending order of relationship. The findings suggest that genetic factors may be associated with a familial tendency for cirrhosis of the liver and HCC.
乙型肝炎病毒（HBV）感染及其相关肝脏疾病在中国具有家族聚集的特征。然而，其原因尚未完全阐明。为了解决这一问题，本研究调查了中国西北地区家族性HBV 感染聚集的流行情况及其不良预后的特征。纳入具有感染聚集和不良预后的家庭，并收集一般信息和血清样本。采用卡方检验或 Fisher 确切概率法比较血缘亲属（包括一级、二级和三级血缘亲属）和配偶之间的 HBV 感染的临床特征和后遗症。共访谈了 102 个具有不良预后的感染聚集家庭。在一级、二级和三级血缘亲属和配偶中，肝硬化的患病率分别为 29.2%、11.9%和 8.7%，而肝癌（HCC）的患病率分别为 21.8%、1.4%和 4.3%（P<0.05）。一级、二级和三级血缘亲属和配偶肝硬化发病的平均年龄分别为 57 ± 9.91、47 ± 9.96、38 ± 10.35 和 57 ± 8.49 岁，HCC 的发病平均年龄分别为 60 ± 7.92、49 ± 8.57、41 ± 3.54 和 50 ± 0 岁，（P<0.05）。具有不良预后的家庭感染聚集的一级、二级和三级血缘亲属中，肝硬化或 HCC 的患病率呈降序排列。这些发现表明遗传因素可能与肝硬化和 HCC 的家族倾向有关。
