合成和应用容纳非常庞大的二-叔丁基膦联芳基配体的钯前催化剂。
Synthesis and application of palladium precatalysts that accommodate extremely bulky di-tert-butylphosphino biaryl ligands.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
Org Lett. 2013 Jun 7;15(11):2876-9. doi: 10.1021/ol401208t. Epub 2013 May 15.
Abstract
A series of palladacyclic precatalysts that incorporate electron-rich di-tert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means of employing bulky ligands in palladium-catalyzed cross-coupling reactions. The application of these palladium sources to various C-N and C-O bond-forming processes is also described.
摘要
本文报道了一系列含有富电子二-叔丁基膦联芳基配体的钯环金属化预催化剂。这些预催化剂易于制备，其使用为在钯催化的交叉偶联反应中采用大位阻配体提供了一种通用手段。还描述了这些钯源在各种 C-N 和 C-O 键形成过程中的应用。
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