Yonova D, Vazelov E, Tzatchev K
Dialysis clinic, UMHAT "Aleksandrovska", Sofia, Bulgaria.
Hippokratia. 2012 Oct;16(4):356-9.
The physiological mechanisms regulating zinc homeostasis in humans have been elucidated and described, but the knowledge of zinc status and zinc distribution in the tissues and in the different biological compartments of patients with conservatively treated chronic renal failure (CRF) and on peritoneal dialysis is still insufficient. This investigation examines and compares zinc content in urine, erythrocytes, plasma, and outflow dialysis solution in a group of continuous ambulatory peritoneal dialysis (CAPD) patients, a group of patients with CRF on conservative treatment and in healthy controls.
Data from the last 6 months of 22 adult hemodialysis patients with a mean age of 61 ± 14 years were analyzed retrospectively. Dialysis vintage, normalized protein catabolic rate (nPCR), serum biochemical parameters, mid arm muscle circumference (MAMC) were determined as mean and standard deviation. Correlations between the variables were computed by coefficient p of Pearson.
In patients on CAPD treatment (group 3) compared to healthy controls (group 1) plasma zinc level was diminished (р<0.05), while erythrocyte zinc elevated (р<0.01). The investigation found out difference between plasma, erythrocyte and urine levels of zinc between the patients with chronic renal failure (group 2) on conservative treatment and those treated by CAPD (group 3), which proves, that continuous ambulatory peritoneal dialysis influences redistribution of zinc in human organism "per se".
调节人体锌稳态的生理机制已得到阐明和描述，但对于保守治疗的慢性肾衰竭（CRF）患者及腹膜透析患者组织和不同生物区室中的锌状态及锌分布情况，我们了解仍不足。本研究对一组持续性非卧床腹膜透析（CAPD）患者、一组接受保守治疗的CRF患者以及健康对照者的尿液、红细胞、血浆和透析流出液中的锌含量进行了检测和比较。
回顾性分析22例平均年龄为61±14岁的成年血液透析患者过去6个月的数据。测定透析龄、标准化蛋白分解代谢率（nPCR）、血清生化参数、上臂中部肌肉周长（MAMC）的均值和标准差。变量之间的相关性通过Pearson系数p计算。
与健康对照者（第1组）相比，CAPD治疗患者（第3组）的血浆锌水平降低（р<0.05），而红细胞锌水平升高（р<0.01）。研究发现，接受保守治疗的慢性肾衰竭患者（第2组）与接受CAPD治疗的患者（第3组）在血浆、红细胞和尿液中的锌水平存在差异，这证明持续性非卧床腹膜透析本身会影响人体锌的重新分布。
