Division of Bioscience and Biotechnology, Department of Biomaterials Engineering, Kangwon National University, Chuncheon 200-701, Republic of Korea.
Evid Based Complement Alternat Med. 2013;2013:464576. doi: 10.1155/2013/464576. Epub 2013 Jul 14.
Codonopsis lanceolata (Campanulaceae) have been traditionally used to treat lung inflammatory diseases, such as asthma, tonsillitis, and pharyngitis. The present study was performed to evaluate the cognitive-enhancing effects of steamed and fermented C. lanceolata in scopolamine-induced memory impairments in mice. Cognitive abilities were determined by the Morris water maze and passive avoidance tests. Mice orally received fermented C. lanceolata extract at doses of 100, 300, or 500 mg/kg body weight. Fermented C. lanceolata extract (500 mg/kg body weight, p.o.) significantly shortened the escape latency times that were increased by scopolamine on the 4th day of trial sessions in the Morris water maze task. In addition, it exerted longer step-through latency times than those of the scopolamine-treated group in the passive avoidance test. Furthermore, the neuroprotective effects of fermented C. lanceolata extract on glutamate-induced neurocytotoxicity were investigated in HT22 cells. Fermented C. lanceolata extract showed a relative protection ratio of 59.62% at 500 μ g/mL. In conclusion, fermented C. lanceolata extract ameliorated scopolamine-induced memory impairments, exerted neuroprotective effects, and improved activity compared to that found with original C. lanceolata. Further study will be required to investigate the mechanisms underlying this cognitive-enhancing activity.
党参（桔梗科）传统上用于治疗肺部炎症性疾病，如哮喘、扁桃体炎和咽炎。本研究旨在评估蒸制和发酵党参对东莨菪碱诱导的小鼠记忆障碍的认知增强作用。通过 Morris 水迷宫和被动回避测试来确定认知能力。小鼠口服给予发酵党参提取物 100、300 或 500mg/kg 体重。发酵党参提取物（500mg/kg 体重，po）可显著缩短东莨菪碱在第 4 天试验中引起的逃避潜伏期时间，在 Morris 水迷宫任务中。此外，它在被动回避测试中的步穿潜伏期时间长于东莨菪碱处理组。此外，还研究了发酵党参提取物对 HT22 细胞中谷氨酸诱导的神经细胞毒性的神经保护作用。发酵党参提取物在 500μg/ml 时的相对保护率为 59.62%。总之，发酵党参提取物改善了东莨菪碱诱导的记忆障碍，与原党参相比，具有神经保护作用和改善的活性。需要进一步研究以探讨这种认知增强活性的机制。
