Cheng Mengqi, Chen Desheng, Guo Yongyuan, Zhu Chen, Zhang Xianlong
Department of Orthopedics, The Sixth Affiliated People's Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200233;
Exp Ther Med. 2013 Jul;6(1):45-51. doi: 10.3892/etm.2013.1122. Epub 2013 May 17.
Controversy exists regarding the clinical and radiological differences in outcomes between fixed-bearing (FB) and mobile-bearing (MB) total knee arthroplasties (TKAs) at the mid- or long-term follow-up. We therefore conducted a meta-analysis and systematic review of randomized controlled trials (RCTs) that have evaluated FB and MB TKAs. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, Medline and Embase. The data, including demographic information, methodological quality, duration of follow-up, clinical and radiographical outcomes, patient preferences and complications, were extracted. The methodological quality of the studies was assessed in accordance with the guidelines presented in the Cochrane Handbook for Systematic Reviews of Interventions. Nine trials, studying 1,821 knees, were eligible for data extraction and meta-analysis. The Knee Society score and the maximum knee flexion demonstrated no difference between the FB and MB groups (P=0.47 and P=0.72, respectively). Similarly, no difference was revealed between the groups for radiological outcomes or general health results. An increased number of high-quality RCTs with long-term follow-ups are required to validate the results.
对于固定平台（FB）和活动平台（MB）全膝关节置换术（TKA）在中长期随访时临床及影像学结果的差异，仍存在争议。因此，我们对评估FB和MB TKA的随机对照试验（RCT）进行了荟萃分析和系统评价。我们检索了Cochrane图书馆中的Cochrane对照试验中心注册库（CENTRAL）、Medline和Embase。提取的数据包括人口统计学信息、方法学质量、随访时间、临床和影像学结果、患者偏好及并发症。根据《Cochrane干预措施系统评价手册》中提出的指南评估研究的方法学质量。九项研究1821例膝关节的试验符合数据提取和荟萃分析的条件。膝关节协会评分和最大膝关节屈曲度在FB组和MB组之间无差异（P分别为0.47和0.72）。同样，两组在影像学结果或总体健康结果方面也未显示出差异。需要更多高质量、长期随访的RCT来验证这些结果。
