Jiang Pu-Cha, Xiong Wen-Ping, Wang Ge, Ma Chao, Yao Wei-Qi, Kendell Steven F, Mehling Brian M, Yuan Xian-Hou, Wu Dong-Cheng
Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Hubei 430071, P.R. China ;
Exp Ther Med. 2013 Jul;6(1):140-146. doi: 10.3892/etm.2013.1083. Epub 2013 Apr 29.
Spinal cord injury (SCI) is a severe neurological disease. An effective strategy for the treatment of SCI is urgently required. Stem cell transplantation has emerged as a viable therapeutic option with great potential for restoring neurological function lost following SCI. From 2009 to 2010, a total of 20 SCI patients were enrolled in a clinical trial by Wuhan Hongqiao Brain Hospital; all patients completed and signed informed consent prior to autologous bone marrow-derived mesenchymal stem cell transplantation. Analysis of subsequent treatment results indicated significant improvements in sensory, motor and autonomic nerve function as assessed by the American Spinal Injury Association's impairment scale. Thirty days after transplantation, a total of 15 patients (75%) demonstrated improvement, including four of the eight patients (50%) with grade A SCI, three of the four patients (75%) with grade B injury and all eight patients (100%) with grade C injury. The most common adverse events, fever and headache, disappeared within 24-48 h without treatment.
脊髓损伤（SCI）是一种严重的神经系统疾病。迫切需要一种有效的脊髓损伤治疗策略。干细胞移植已成为一种可行的治疗选择，在恢复脊髓损伤后丧失的神经功能方面具有巨大潜力。2009年至2010年，武汉虹桥脑科医院共有20例脊髓损伤患者参加了一项临床试验；所有患者在进行自体骨髓间充质干细胞移植前均完成并签署了知情同意书。对后续治疗结果的分析表明，根据美国脊髓损伤协会的损伤量表评估，感觉、运动和自主神经功能有显著改善。移植后30天，共有15例患者（75%）病情改善，其中8例A级脊髓损伤患者中有4例（50%）、4例B级损伤患者中有3例（75%）、8例C级损伤患者全部（100%）病情改善。最常见的不良事件，发热和头痛，未经治疗在24 - 48小时内消失。
