Department of Neuroscience and Imaging, University G d'Annunzio Chieti-Pescara, Italy.
PLoS One. 2013 Jul 25;8(7):e69224. doi: 10.1371/journal.pone.0069224. Print 2013.
There is growing debate on the use of drugs that promote cognitive enhancement. Amphetamine-like drugs have been employed as cognitive enhancers, but they show important side effects and induce addiction. In this study, we investigated the use of modafinil which appears to have less side effects compared to other amphetamine-like drugs. We analyzed effects on cognitive performances and brain resting state network activity of 26 healthy young subjects.
A single dose (100 mg) of modafinil was administered in a double-blind and placebo-controlled study. Both groups were tested for neuropsychological performances with the Raven's Advanced Progressive Matrices II set (APM) before and three hours after administration of drug or placebo. Resting state functional magnetic resonance (rs-FMRI) was also used, before and after three hours, to investigate changes in the activity of resting state brain networks. Diffusion Tensor Imaging (DTI) was employed to evaluate differences in structural connectivity between the two groups. Protocol ID: Modrest_2011; NCT01684306; http://clinicaltrials.gov/ct2/show/NCT01684306.
Results indicate that a single dose of modafinil improves cognitive performance as assessed by APM. Rs-fMRI showed that the drug produces a statistically significant increased activation of Frontal Parietal Control (FPC; p<0.04) and Dorsal Attention (DAN; p<0.04) networks. No modifications in structural connectivity were observed.
Overall, our findings support the notion that modafinil has cognitive enhancing properties and provide functional connectivity data to support these effects.
ClinicalTrials.gov NCT01684306 http://clinicaltrials.gov/ct2/show/NCT01684306.
关于使用促进认知增强的药物的争论越来越多。安非他命类药物已被用作认知增强剂，但它们表现出重要的副作用并引起成瘾。在这项研究中，我们研究了莫达非尼的使用情况，与其他安非他命类药物相比，它的副作用似乎较少。我们分析了 26 名健康年轻受试者的认知表现和大脑静息状态网络活动的变化。
在一项双盲、安慰剂对照研究中，给 26 名健康年轻受试者单剂量（100mg）莫达非尼。两组受试者在给药或安慰剂前和给药后 3 小时均接受瑞文高级渐进矩阵 II 集（APM）的神经心理学测试。静息态功能磁共振（rs-FMRI）也在给药前和 3 小时后使用，以研究静息态脑网络活动的变化。扩散张量成像（DTI）用于评估两组之间结构连接的差异。方案 ID：Modrest_2011；NCT01684306；http://clinicaltrials.gov/ct2/show/NCT01684306。
结果表明，单次剂量的莫达非尼可改善 APM 评估的认知表现。rs-fMRI 显示，该药物可使额顶控制（FPC；p<0.04）和背侧注意（DAN；p<0.04）网络的激活显著增加。未观察到结构连接的改变。
总的来说，我们的研究结果支持莫达非尼具有认知增强特性的观点，并提供功能连接数据支持这些作用。
ClinicalTrials.gov NCT01684306 http://clinicaltrials.gov/ct2/show/NCT01684306。
