Olazadeh Keyvan, Borumandnia Nasrin, Khadembashi Naghmeh, Alavi Majd Hamid
Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Urology and Nephrology Research Centre, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Am J Neurodegener Dis. 2022 Apr 15;11(1):1-9. eCollection 2022.
Examining the differences in the Functional Connectivity (FC) network while using Functional Magnetic Resonance Imaging (fMRI) between two groups can expand the understanding of neural processes and help diagnose and prevent neurological progression disorders. The present study evaluated the Modafinil effect on the FC of brain Regions of Interest (ROI) among healthy young individuals between the Modafinil and placebo groups.
The data used in this study were downloaded from the open fMRI site and analyzed after preprocessing. Data included brain scan images of 26 healthy young men with no history of neurological disorders. These people are divided into two groups of drugs and a placebo. The drug group was given 100 mg of Modafinil, and the placebo group was assigned the same dose. Data were analyzed using a longitudinal variance component model.
After taking the drug and placebo by the two groups, the study of the difference between FC in the drug and placebo group and the baseline effect showed a statistically significant difference in one pair of ROIs. Also, in examining the difference between FC in the drug and placebo groups of the longitudinal trend, there was a statistically significant difference between 5 pairs of ROIs.
After taking Modafinil and placebo, it was observed that FC in most areas in the drug group increased compared to the placebo group, indicating Modafinil has cognitive enhancement properties and has a role in visual, auditory, memory learning, and self-awareness functions and enhances these functions.
使用功能磁共振成像（fMRI）检查两组之间功能连接（FC）网络的差异，可以扩展对神经过程的理解，并有助于诊断和预防神经进展性疾病。本研究评估了莫达非尼对健康年轻个体中感兴趣脑区（ROI）的FC的影响，比较了莫达非尼组和安慰剂组。
本研究中使用的数据从开放的fMRI网站下载，并在预处理后进行分析。数据包括26名无神经疾病史的健康年轻男性的脑部扫描图像。这些人被分为药物组和安慰剂组。药物组给予100毫克莫达非尼，安慰剂组给予相同剂量。使用纵向方差成分模型分析数据。
两组服用药物和安慰剂后，对药物组和安慰剂组之间FC的差异以及基线效应的研究表明，在一对ROI中存在统计学上的显著差异。此外，在检查药物组和安慰剂组纵向趋势的FC差异时，在5对ROI之间存在统计学上的显著差异。
服用莫达非尼和安慰剂后，观察到药物组中大多数区域的FC与安慰剂组相比有所增加，表明莫达非尼具有认知增强特性，并且在视觉、听觉、记忆学习和自我意识功能中起作用，并增强这些功能。
