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从新西兰罗托伊蒂湖分离出的一种微囊藻毒素降解细菌对[Dha(7)]MC-LR的降解作用

Degradation of [Dha(7)]MC-LR by a Microcystin Degrading Bacterium Isolated from Lake Rotoiti, New Zealand.

作者信息

Somdee Theerasak, Thunders Michelle, Ruck John, Lys Isabelle, Allison Margaret, Page Rachel

机构信息

Faculty of Sciences, Khon Kaen University, Khon Kaen 40000, Thailand.

出版信息

ISRN Microbiol. 2013 Jun 27;2013:596429. doi: 10.1155/2013/596429. Print 2013.

DOI:10.1155/2013/596429
PMID:23936728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3712209/
Abstract

For the first time a microcystin-degrading bacterium (NV-3 isolate) has been isolated and characterized from a NZ lake. Cyanobacterial blooms in New Zealand (NZ) waters contain microcystin (MC) hepatotoxins at concentrations which are a risk to animal and human health. Degradation of MCs by naturally occurring bacteria is an attractive bioremediation option for removing MCs from drinking and recreational water sources. The NV-3 isolate was identified by 16S rRNA sequence analysis and found to have 100% nucleotide sequence homology with the Sphingomonas MC-degrading bacterial strain MD-1 from Japan. The NV-3 isolate (concentration of 1.0 × 10(8) CFU/mL) at 30°C degraded a mixture of [Dha(7)]MC-LR and MC-LR (concentration 25  μ g/mL) at a maximum rate of 8.33  μ g/mL/day. The intermediate by-products of [Dha(7)]MC-LR degradation were detected and similar to MC-LR degradation by-products. The presence of three genes (mlrA, mlrB, and mlrC), that encode three enzymes involved in the degradation of MC-LR, were identified in the NV-3 isolate. This study confirmed that degradation of [Dha(7)]MC-LR by the Sphingomonas isolate NV-3 occurred by a similar mechanism previously described for MC-LR by Sphingomonas strain MJ-PV (ACM-3962). This has important implications for potential bioremediation of toxic blooms containing a variety of MCs in NZ waters.

摘要

首次从新西兰的一个湖泊中分离并鉴定出一种微囊藻毒素降解细菌（NV-3菌株）。新西兰水域的蓝藻水华中含有微囊藻毒素（MC）肝毒素，其浓度对动物和人类健康构成风险。天然存在的细菌对MC的降解是一种从饮用水和娱乐用水水源中去除MC的有吸引力的生物修复选择。通过16S rRNA序列分析鉴定了NV-3菌株，发现其与来自日本的鞘氨醇单胞菌MC降解菌株MD-1具有100%的核苷酸序列同源性。NV-3菌株（浓度为1.0×10⁸ CFU/mL）在30°C下以最大速率8.33 μg/mL/天降解了[Dha(7)]MC-LR和MC-LR的混合物（浓度为25 μg/mL）。检测到了[Dha(7)]MC-LR降解的中间副产物，且与MC-LR降解副产物相似。在NV-3菌株中鉴定出了三个基因（mlrA、mlrB和mlrC），它们编码参与MC-LR降解的三种酶。这项研究证实，鞘氨醇单胞菌分离株NV-3对[Dha(7)]MC-LR的降解机制与之前鞘氨醇单胞菌菌株MJ-PV（ACM-3962）对MC-LR的降解机制相似。这对于新西兰水域中含有多种MC的有毒水华的潜在生物修复具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68f/3712209/09f2bc5aa772/ISRN.MICROBIOLOGY2013-596429.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68f/3712209/57f9796a23f2/ISRN.MICROBIOLOGY2013-596429.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68f/3712209/e179b06fabd7/ISRN.MICROBIOLOGY2013-596429.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68f/3712209/09f2bc5aa772/ISRN.MICROBIOLOGY2013-596429.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68f/3712209/57f9796a23f2/ISRN.MICROBIOLOGY2013-596429.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68f/3712209/e179b06fabd7/ISRN.MICROBIOLOGY2013-596429.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a68f/3712209/09f2bc5aa772/ISRN.MICROBIOLOGY2013-596429.003.jpg

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