BioEngLab, Health Science and Technology-Interdepartmental Center for Industrial Research (HST-CIRI), University of Bologna, I-40064 Ozzano Emilia, Italy.
Biomed Res Int. 2013;2013:918640. doi: 10.1155/2013/918640. Epub 2013 Jul 8.
Owing to the inability of self-replacement by a damaged myocardium, alternative strategies to heart transplantation have been explored within the last decades and cardiac tissue engineering/regenerative medicine is among the present challenges in biomedical research. Hopefully, several studies witness the constant extension of the toolbox available to engineer a fully functional, contractile, and robust cardiac tissue using different combinations of cells, template bioscaffolds, and biophysical stimuli obtained by the use of specific bioreactors. Mechanical forces influence the growth and shape of every tissue in our body generating changes in intracellular biochemistry and gene expression. That is why bioreactors play a central role in the task of regenerating a complex tissue such as the myocardium. In the last fifteen years a large number of dynamic culture devices have been developed and many results have been collected. The aim of this brief review is to resume in a single streamlined paper the state of the art in this field.
由于受损心肌无法自我替代，过去几十年来，人们一直在探索替代心脏移植的策略，心脏组织工程/再生医学是当前生物医学研究中的挑战之一。希望有几项研究见证了工具包的不断扩展，该工具包可用于使用不同细胞组合、模板生物支架和通过使用特定生物反应器获得的生物物理刺激来构建具有完全功能、收缩和强健的心脏组织。机械力会影响我们体内每个组织的生长和形状，从而导致细胞内生化和基因表达的变化。这就是为什么生物反应器在再生心肌等复杂组织的任务中起着核心作用。在过去的十五年中，已经开发出了大量的动态培养设备，并收集了许多结果。本文的目的是在一篇简明的论文中总结该领域的最新进展。
