葡萄糖波动对 2 型糖尿病患者冠状动脉疾病严重程度的影响。
The effects of glucose fluctuation on the severity of coronary artery disease in type 2 diabetes mellitus.
机构信息
General Hospital of Beijing Military Region, No. 5 Nan Men Cang, Dongcheng Distrct, Beijing 100700, China.
出版信息
J Diabetes Res. 2013;2013:576916. doi: 10.1155/2013/576916. Epub 2013 Jul 7.
Abstract
OBJECTIVES
To explore the difference of glucose fluctuations between the normal subjects and diabetes mellitus (DM) patients and explore their impact on the development of CAD in type 2 DM patients.
METHODS
The subjects were divided into 3 groups: normal control (group A, n = 40), type 2 DM patients without cardiovascular complications (group B, n = 56), and type 2 DM patients with cardiovascular complications (group C, n = 92). The SYNTAX scores were collected in group C. CGMS for 72 h was applied on all the subjects. The indexes such as MBG and the LAGE were calculated. Glycemic excursions were compared between groups A, B, and C, respectively.
RESULTS
The tested indexes had significant differences among the three groups. SYNTAX scores are related to systolic blood pressure, CRP, MAGE, and HbA1c and are significantly correlated at 6:00-8:00 and 11:00-13:00 time points in group C.
CONCLUSIONS
Compared with normal subjects, T2DM patients have greater blood glucose fluctuations; T2DM patients with CAD have larger glucose fluctuations than T2DM patients without CAD. Blood glucose fluctuations are positively correlated with carotid artery intima-media thickness in T2DM patients and have a significant influence on the development of coronary artery.
摘要
目的
探讨正常人与糖尿病患者之间血糖波动的差异，并探讨其对 2 型糖尿病患者发生 CAD 的影响。
方法
将受试者分为 3 组：正常对照组（A 组，n=40）、无心血管并发症的 2 型糖尿病患者（B 组，n=56）和有心血管并发症的 2 型糖尿病患者（C 组，n=92）。在 C 组收集 SYNTAX 评分。所有受试者均应用 CGMS 进行 72 h 监测，计算 MBG 和 LAGE 等指标。分别比较 A、B 和 C 组之间的血糖波动。
结果
三组之间的测试指标存在显著差异。SYNTAX 评分与收缩压、CRP、MAGE 和 HbA1c 相关，在 C 组 6：00-8：00 和 11：00-13：00 时间点显著相关。
结论
与正常受试者相比，T2DM 患者的血糖波动更大；合并 CAD 的 T2DM 患者的血糖波动大于无 CAD 的 T2DM 患者。血糖波动与 T2DM 患者颈动脉内膜中层厚度呈正相关，对冠状动脉的发生发展有显著影响。
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