Arranz-Marquez Esther, Bolivar Gema, Piñero David P, Konstas Anastasios G P, Mikropoulos Dimitrios G, Teus Miguel A
*MD, PhD †PhD Rey Juan Carlos Hospital, Móstoles, Madrid, Spain (EA-M); Novovision, Madrid, Spain (EA-M, MAT); "Príncipe de Asturias" Universitary Hospital, Madrid, Spain (GB, MAT); Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain (DPP); Foundation for the Visual Quality (FUNCAVIS), Alicante, Spain (DPP); 1st University, Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece (AGPK, DGM); and University of Alcalá, Madrid, Spain (MAT).
Optom Vis Sci. 2013 Oct;90(10):1098-103. doi: 10.1097/OPX.0000000000000019.
To compare anterior and posterior corneal curvatures between eyes with primary open-angle glaucoma (POAG) and healthy eyes.
This is a prospective, cross-sectional, observer-masked study. A total of 138 white subjects (one eye per patient) were consecutively recruited; 69 eyes had POAG (study group), and the other 69 comprised a group of healthy control eyes matched for age and central corneal pachymetry with the study ones. Exclusion criteria included any corneal or ocular inflammatory disease, previous ocular surgery, or treatment with carbonic anhydrase inhibitors. The same masked observer performed Goldmann applanation tonometry, ultrasound pachymetry, and Orbscan II topography in all cases. Central corneal thickness, intraocular pressure, and anterior and posterior topographic elevation maps were analyzed and compared between both groups.
Patients with POAG had greater forward shifting of the posterior corneal surface than that in healthy control eyes (p < 0.01). Significant differences in anterior corneal elevation between controls and POAG eyes were also found (p < 0.01).
Primary open-angle glaucoma eyes have a higher elevation of the posterior corneal surface than that in central corneal thickness-matched nonglaucomatous eyes.
比较原发性开角型青光眼（POAG）患者与健康人眼睛的角膜前、后曲率。
这是一项前瞻性、横断面、观察者盲法研究。连续招募了138名白人受试者（每位患者一只眼睛）；69只眼睛患有POAG（研究组），另外69只构成一组与研究组年龄和中央角膜厚度相匹配的健康对照眼睛。排除标准包括任何角膜或眼部炎症性疾病、既往眼部手术或使用碳酸酐酶抑制剂治疗。所有病例均由同一位盲法观察者进行Goldmann压平眼压测量、超声测厚和Orbscan II地形图检查。分析并比较两组的中央角膜厚度、眼压以及前、后地形高度图。
POAG患者的角膜后表面向前移位比健康对照眼睛更明显（p < 0.01）。对照组和POAG眼睛之间的角膜前表面高度也存在显著差异（p < 0.01）。
原发性开角型青光眼患者的角膜后表面高度高于中央角膜厚度匹配的非青光眼眼睛。
