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帕金森病的睡眠获益:是时候解开这个谜团了?

Sleep benefit in Parkinson's disease: time to revive an enigma?

机构信息

Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

出版信息

J Parkinsons Dis. 2012;2(2):167-70. doi: 10.3233/JPD-2012-12087.

DOI:10.3233/JPD-2012-12087
PMID:23939441
Abstract

Some patients with Parkinson's disease (PD) reportedly experience 'sleep benefit': an improved motor functioning upon awaking in the morning. In this questionnaire study, 114 out of 243 consecutive outpatients with PD (46.9%) subjectively experienced sleep benefit. Among those patients that regularly took an afternoon nap, 33.7% experienced sleep benefit after the nap as well. Between patients with and without sleep benefit, there were no differences in demographic or clinical variables, including age, disease duration, dopaminergic treatment, and nocturnal sleep quality. Sleep benefit remains an intriguing but elusive phenomenon, which deserves renewed attention and further research.

摘要

一些帕金森病(PD)患者据称经历了“睡眠获益”:早晨醒来时运动功能得到改善。在这项问卷调查研究中,243 名连续门诊 PD 患者中有 114 名(46.9%)主观上经历了睡眠获益。在那些经常在下午小睡的患者中,33.7%的人在小睡后也经历了睡眠获益。在有睡眠获益和无睡眠获益的患者之间,在人口统计学或临床变量方面没有差异,包括年龄、疾病持续时间、多巴胺能治疗和夜间睡眠质量。睡眠获益仍然是一个有趣但难以捉摸的现象,值得重新关注和进一步研究。

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The related factors of sleep benefit in Parkinson's disease: A systematic review and meta-analysis.帕金森病睡眠获益的相关因素:系统评价和荟萃分析。
PLoS One. 2019 Mar 11;14(3):e0212951. doi: 10.1371/journal.pone.0212951. eCollection 2019.
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Objective Measurement and Characterization of Sleep Benefit in Parkinson's Disease.帕金森病睡眠益处的客观测量与特征分析
Mov Disord Clin Pract. 2017 May 25;4(4):590-596. doi: 10.1002/mdc3.12489. eCollection 2017 Jul-Aug.
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Quantitative Motor Performance and Sleep Benefit in Parkinson Disease.帕金森病的定量运动表现与睡眠益处
Sleep. 2015 Oct 1;38(10):1567-73. doi: 10.5665/sleep.5048.
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Prospective assessment of subjective sleep benefit in Parkinson's disease.帕金森病主观睡眠益处的前瞻性评估。
BMC Neurol. 2015 Jan 16;15:2. doi: 10.1186/s12883-014-0256-2.
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Tremor and clinical fluctuation are related to sleep disorders in Chinese patients with Parkinson's disease.在中国帕金森病患者中,震颤和临床波动与睡眠障碍有关。
Transl Neurodegener. 2014 Oct 22;3:21. doi: 10.1186/2047-9158-3-21. eCollection 2014.