Nicholas M K, Asghari A, Sharpe L, Brnabic A, Wood B M, Overton S, Tonkin L, de Sousa M, Finniss D, Beeston L, Sutherland A, Corbett M, Brooker C
Pain Management Research Institute, University of Sydney at Royal North Shore Hospital, Australia.
Eur J Pain. 2014 Mar;18(3):424-37. doi: 10.1002/j.1532-2149.2013.00383.x. Epub 2013 Aug 13.
Behavioural exposure methods can reduce pain-avoidance behaviours, but outcomes vary. One possible explanation is that patients employ cognitive (experiential) avoidance during behavioural exposure. If so, reducing cognitive avoidance during behavioural exposure should help. One option is interoceptive exposure (IE), which involves sustained exposure (via attention) to pain sensations. In order to test if IE could improve outcomes from behavioural exposure, this study with mixed chronic pain patients compared outcomes from a cognitive behavioural therapy (CBT) pain management programme incorporating either IE or distraction from pain.
One hundred forty chronic pain patients were randomly assigned to CBT + IE or CBT + distraction. Outcome measures included pain, disability, depression and medication. Measures reflecting degree of threat of pain were also employed (catastrophizing, fear-avoidance, pain self-efficacy and pain acceptance). An intention-to-treat approach, using mixed-effects model repeated measures, as well as conventional inferential statistical tests, effect sizes and reliable change indices were employed to evaluate the outcomes up to 1-year post-treatment.
Significant improvements were achieved by both treatment conditions on all outcome measures and on measures reflecting the threatening nature of pain, with no differences between treatment conditions.
The addition of IE to behavioural exposure did not improve outcomes. However, higher adherence to either attentional strategy was associated with larger effect sizes on all measures, suggesting factors shared by the two treatments could have contributed to the outcomes. Taken as a whole, the results suggest that increasing adherence to treatment strategies, possibly by motivational measures, would improve the overall outcomes of these interventions.
行为暴露方法可以减少疼痛回避行为,但结果各不相同。一种可能的解释是,患者在行为暴露过程中采用认知(体验性)回避。如果是这样,在行为暴露过程中减少认知回避应该会有所帮助。一种选择是内感受暴露(IE),即通过注意力持续暴露于疼痛感觉。为了测试IE是否可以改善行为暴露的结果,这项针对慢性疼痛混合患者的研究比较了认知行为疗法(CBT)疼痛管理计划的结果,该计划包括IE或分散对疼痛的注意力。
140名慢性疼痛患者被随机分配到CBT + IE组或CBT + 分散注意力组。结果测量包括疼痛、残疾、抑郁和药物治疗。还采用了反映疼痛威胁程度的测量方法(灾难化、恐惧回避、疼痛自我效能感和疼痛接受度)。采用意向性分析方法,使用混合效应模型重复测量,以及传统的推断统计检验、效应量和可靠变化指数来评估治疗后长达1年的结果。
两种治疗条件在所有结果测量以及反映疼痛威胁性质的测量上均取得了显著改善,治疗条件之间没有差异。
在行为暴露中添加IE并没有改善结果。然而,对任何一种注意力策略的更高依从性与所有测量上更大的效应量相关,这表明两种治疗方法共有的因素可能对结果有贡献。总体而言,结果表明,可能通过动机性措施提高对治疗策略的依从性,将改善这些干预措施的总体结果。