Sarawak Biodiversity Centre (SBC), KM 20 Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, 93990 Kuching, Sarawak, Malaysia.
Chem Biodivers. 2013 Aug;10(8):1475-86. doi: 10.1002/cbdv.201200303.
Photodynamic therapy (PDT) is a medical treatment that involves the irradiation of an administered photosensitizing drug with light of a particular wavelength to activate the photosensitizer to kill abnormal cells. To date, only a small number of photosensitizers have been clinically approved for PDT, and researchers continue to look for new molecules that have more desirable properties for clinical applications. Natural products have long been important sources of pharmaceuticals, and there is a great potential for discovery of novel chemotypes from under-explored biodiversities in the world. The objective of this study is to mine the terrestrial plants in Sarawak, Borneo Island, for new photosensitizers for PDT. In a screening program from 2004 to 2008, we prepared and studied 2,400 extracts from 888 plants for their photosensitizing activities. This report details the bioprospecting process, preparation and testing of extracts, analysis of the active samples, fractionation of four samples, and isolation and characterization of photosensitizers.
光动力疗法（PDT）是一种医疗治疗方法，涉及用特定波长的光照射给予的光敏药物，以激活光敏剂来杀死异常细胞。迄今为止，只有少数几种光敏药物被临床批准用于 PDT，研究人员仍在寻找具有更理想临床应用特性的新分子。天然产物长期以来一直是药物的重要来源，从世界上尚未充分探索的生物多样性中发现新的化学型具有巨大的潜力。本研究的目的是从婆罗洲的沙捞越陆地植物中挖掘用于 PDT 的新型光敏剂。在 2004 年至 2008 年的筛选计划中，我们从 888 种植物中制备并研究了 2400 种提取物，以研究它们的光敏活性。本报告详细介绍了生物勘探过程、提取物的制备和测试、活性样品的分析、四个样品的分离以及光敏剂的分离和表征。
