2007 年至 2012 年加拿大 CANWARD 研究中，从加拿大医院患者分离的铜绿假单胞菌对头孢洛扎-他唑巴坦的体外活性。
In vitro activity of ceftolozane-tazobactam against Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals in the CANWARD study, 2007 to 2012.
机构信息
Departments of Medicine and Clinical Microbiology, Health Sciences Centre.
出版信息
Antimicrob Agents Chemother. 2013 Nov;57(11):5707-9. doi: 10.1128/AAC.01404-13. Epub 2013 Aug 12.
Abstract
The in vitro activity of ceftolozane in combination with tazobactam (fixed concentration of 4 μg/ml) was evaluated against 2,435 Pseudomonas aeruginosa clinical isolates obtained from across Canada using Clinical and Laboratory Standards Institute broth microdilution methods. The MIC50 and MIC90 values for ceftolozane-tazobactam were 0.5 μg/ml and 1 μg/ml, respectively (a 32-fold-lower MIC90 than that for ceftazidime). Eighty-nine percent (141/158) of multidrug-resistant isolates were inhibited by ≤8 μg/ml of ceftolozane-tazobactam.
摘要
采用临床和实验室标准协会肉汤微量稀释法，评估了头孢洛扎他唑巴坦（固定浓度为 4μg/ml）组合对来自加拿大各地的 2435 株铜绿假单胞菌临床分离株的体外活性。头孢洛扎他唑巴坦的 MIC50 和 MIC90 值分别为 0.5μg/ml 和 1μg/ml（MIC90 比头孢他啶低 32 倍）。89%（141/158）的多重耐药分离株被≤8μg/ml 的头孢洛扎他唑巴坦抑制。
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