Department of Global Health, University of Washington, Seattle, WA 98104, USA.
Bull World Health Organ. 2013 Aug 1;91(8):585-92. doi: 10.2471/BLT.12.113837. Epub 2013 Jun 19.
To estimate the incremental delivery cost of human papillomavirus (HPV) vaccination of young adolescent girls in Peru, Uganda and Viet Nam.
Data were collected from a sample of facilities that participated in five demonstration projects for hpv vaccine delivery: school-based delivery was used in Peru, Uganda and Viet Nam; health-centre-based delivery was also used in Viet Nam; and integrated delivery, which involved existing health services, was also used in Uganda. Microcosting methods were used to guide data collection on the use of resources (i.e. staff, supplies and equipment) and data were obtained from government, demonstration project and health centre administrative records. Delivery costs were expressed in 2009 United States dollars (US$). Exclusively project-related expenses and the cost of the vaccine were excluded.
The economic delivery cost per vaccine dose ranged from US$ 1.44 for integrated outreach in Uganda to US$ 3.88 for school-based delivery in Peru. In Viet Nam, the lowest cost per dose was US$ 1.92 for health-centre-based delivery. Cost profiles revealed that, in general, the largest contributing factors were project start-up costs and recurrent personnel costs. The delivery cost of HPV vaccine was higher than published costs for traditional vaccines recommended by the Expanded Programme on Immunization (EPI).
The cost of delivering HPV vaccine to young adolescent girls in Peru, Uganda and Viet Nam was higher than that for vaccines currently in the EPI schedule. The cost per vaccine dose was lower when delivery was integrated into existing health services.
估计在秘鲁、乌干达和越南为少女接种人乳头瘤病毒(HPV)疫苗的额外交付成本。
数据来自参与五项 HPV 疫苗接种示范项目的设施样本收集:秘鲁、乌干达和越南采用了基于学校的接种方式;越南还采用了基于卫生中心的接种方式;乌干达采用了整合交付方式,涉及现有卫生服务。微观成本核算方法用于指导资源使用数据(即人员、用品和设备)的收集,并从政府、示范项目和卫生中心行政记录中获取数据。交付成本以 2009 年美元(USD)表示。不包括与项目相关的费用和疫苗成本。
每支疫苗的经济交付成本范围从乌干达整合外展的 1.44 美元到秘鲁基于学校的接种的 3.88 美元。在越南,基于卫生中心的接种成本最低,每支疫苗为 1.92 美元。成本概况表明,一般来说,最大的贡献因素是项目启动成本和经常性人员成本。HPV 疫苗的交付成本高于扩大免疫规划(EPI)推荐的传统疫苗公布成本。
在秘鲁、乌干达和越南为少女接种 HPV 疫苗的交付成本高于 EPI 计划中目前的疫苗。当交付整合到现有卫生服务中时,每支疫苗的成本更低。